Search International and National Patent Collections

1. (WO2002002743) THE NIP3 FAMILY OF PROTEINS

Pub. No.:    WO/2002/002743    International Application No.:    PCT/US2001/021043
Publication Date: Jan 10, 2002 International Filing Date: Jun 29, 2001
IPC: A61K 48/00
C07K 14/47
Applicants: UNIVERSITY OF MANITOBA
KOHN, Kenneth, I.
Inventors: KOHN, Kenneth, I.
GREENBERG, Arnold, H.
Title: THE NIP3 FAMILY OF PROTEINS
Abstract:
There is provided an isolated and purified BNIP3 protein. There is also provided a method for inducing necrosis in cells by transfecting a cell with a BNIP3 protein. A method for inducing necrosis in cells by creating a transgene overexpressing the gene for the BNIP3 protein is also provided. A transgenic animal and progeny thereof is provided having an expression factor consisting essentially of a BNIP3 protein selected from the group consisting essentially of Seq. ID 1 and 2. Also provided is a vector for use in treating disease including BNIP3 or DN NIP and a promoter. A gene therapy having DNA encoding BNIP3 or DN NIP and a promoter, whereby said gene therapy is used to induce necrosis or inhibit necrosis is also provided.