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1. WO2002002596 - SYNTHETIC METHODS FOR APLIDINE AND NEW ANTITUMORAL DERIVATIVES, METHODS OF MAKING AND USING THEM

Publication Number WO/2002/002596
Publication Date 10.01.2002
International Application No. PCT/GB2001/002901
International Filing Date 02.07.2001
Chapter 2 Demand Filed 29.01.2002
IPC
A61K 38/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 5/02 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
02containing at least one abnormal peptide link
C07K 5/083 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
08Tripeptides
083the side chain of the first amino acid being acyclic, e.g. Gly, Ala
C07K 7/02 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
7Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
02Linear peptides containing at least one abnormal peptide link
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07K 11/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
11Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
C07K 5/0205
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
02containing at least one abnormal peptide link
0205containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
C07K 5/0808
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
08Tripeptides
0802with the first amino acid being neutral
0804and aliphatic
0808the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
C07K 7/02
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
7Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
02Linear peptides containing at least one abnormal peptide link
Applicants
  • PHARMA MAR, S.A. [ES]/[ES] (AllExceptUS)
  • RODRIGUEZ, Ignacio [ES]/[ES] (UsOnly)
  • POLANCO, Concepción [ES]/[ES] (UsOnly)
  • CUEVAS, Felix [ES]/[ES] (UsOnly)
  • MANDEZ, Paloma [ES]/[ES] (UsOnly)
  • CUEVAS, Carmen [ES]/[ES] (UsOnly)
  • GALLEGO, Pilar [ES]/[ES] (UsOnly)
  • MUNT, Simon [GB]/[ES] (UsOnly)
  • MANZANARES, Ignacio [ES]/[ES] (UsOnly)
Inventors
  • RODRIGUEZ, Ignacio
  • POLANCO, Concepción
  • CUEVAS, Felix
  • MANDEZ, Paloma
  • CUEVAS, Carmen
  • GALLEGO, Pilar
  • MUNT, Simon
  • MANZANARES, Ignacio
Agents
  • RUFFLES, Graham, Keith
Priority Data
0016148.930.06.2000GB
0103750.615.02.2001GB
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) SYNTHETIC METHODS FOR APLIDINE AND NEW ANTITUMORAL DERIVATIVES, METHODS OF MAKING AND USING THEM
(FR) PROCEDES DE SYNTHESE POUR L'APLIDINE ET DE NOUVEAUX DERIVES ANTITUMORAUX, LEUR PROCEDE DE PRODUCTION ET D'UTILISATION
Abstract
(EN) The invention provides aplidine derivatives and synthetic methods. They are represented by the formula: where the different symbols have the meaning indicated in the description.
(FR) L'invention concerne des dérivés d'aplidine et des procédés de synthèse.
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