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Machine translation
1. (WO2002002548) COUMARIN DERIVATIVES WITH COMT INHIBITING ACTIVITY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2002/002548    International Application No.:    PCT/FI2001/000613
Publication Date: 10.01.2002 International Filing Date: 28.06.2001
Chapter 2 Demand Filed:    14.12.2001    
IPC:
A61K 31/435 (2006.01), A61K 31/47 (2006.01), C07D 311/16 (2006.01), C07D 311/76 (2006.01), C07D 405/04 (2006.01)
Applicants: ORION CORPORATION [FI/FI]; Orionintie 1 FIN-02200 Espoo (FI) (For All Designated States Except US).
PYSTYNEN, Jarmo [FI/FI]; (FI) (For US Only).
OVASKA, Martti [FI/FI]; (FI) (For US Only).
VIDGREN, Jukka [FI/FI]; (FI) (For US Only).
LOTTA, Timo [FI/FI]; (FI) (For US Only).
YLIPERTTULA-IKONEN, Marjo [FI/FI]; (FI) (For US Only)
Inventors: PYSTYNEN, Jarmo; (FI).
OVASKA, Martti; (FI).
VIDGREN, Jukka; (FI).
LOTTA, Timo; (FI).
YLIPERTTULA-IKONEN, Marjo; (FI)
Agent: ORION CORPORATION; Orion Pharma Industrial Property Rights P.O. Box 65 FIN-02101 Espoo (FI)
Priority Data:
20001593 03.07.2000 FI
Title (EN) COUMARIN DERIVATIVES WITH COMT INHIBITING ACTIVITY
(FR) DERIVES DE COUMARINE AYANT UNE ACTIVITE D'INHIBITION DE LA COMT
Abstract: front page image
(EN)Compounds of formula (I') wherein the two OH- substituents in the phenyl moiety are in a position ortho to one another and R1 in a position ortho to one of the hydroxy groups; and X, R¿1? to R¿6? are as defined in claims, exhibit COMT enzyme inhibiting activity so that they are useful as COMT inhibitors.
(FR)La présente invention concerne des composés de formule (I') dans laquelle: les substituants OH- de la fraction phényle se trouvent dans une position ortho l'un par rapport à l'autre, et R1 se trouve dans une position ortho par rapport à l'un des groupes hydroxy; et X, R¿1? à R¿6? correspondent aux éléments indiqués dans les revendications. Lesdits composés présentent une activité d'inhibition de l'enzyme COMT de sorte qu'ils peuvent être utilisés comme inhibiteurs de la COMT.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)