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1. (WO2002002143) ENHANCEMENT OF ANTIBODY-CYTOKINE FUSION PROTEIN MEDIATED IMMUNE RESPONSES BY COMBINED TREATMENT WITH IMMUNOCYTOKINE UPTAKE ENHANCING AGENTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2002/002143    International Application No.:    PCT/US2001/020958
Publication Date: 10.01.2002 International Filing Date: 29.06.2001
Chapter 2 Demand Filed:    25.01.2002    
IPC:
A61K 31/282 (2006.01), A61K 31/337 (2006.01), A61K 31/675 (2006.01), A61K 38/20 (2006.01), A61K 39/395 (2006.01), C07K 16/30 (2006.01)
Applicants: LEXIGEN PHARMACEUTICALS CORP. [US/US]; 125 Hartwell Avenue Lexington, MA 02421-3125 (US)
Inventors: GILLIES, Stephen, D.; (US).
LAN, Yan; (US).
HOLDEN, Sylvia, A.; (US)
Agent: WALLER, Patrick, R., H.; Testa, Hurwitz & Thibeault, L.L.P. High Street Tower 125 High Street Boston, MA 02110 (US)
Priority Data:
60/215,038 29.06.2000 US
Title (EN) ENHANCEMENT OF ANTIBODY-CYTOKINE FUSION PROTEIN MEDIATED IMMUNE RESPONSES BY COMBINED TREATMENT WITH IMMUNOCYTOKINE UPTAKE ENHANCING AGENTS
(FR) RENFORCEMENT DES REPONSES IMMUNITAIRES DONT LA MEDIATION EST ASSUREE PAR UNE PROTEINE DE FUSION ANTICORP-CYTOKINE VIA LE TRAITEMENT COMBINE A BASE D'AGENTS AMELIORANT LA FIXATION DES IMMUNOCYTOKINES
Abstract: front page image
(EN)Disclosed are methods and compositions for treating tumors. Disclosed methods and compositions enhance the uptake of immunocytokines into tumors, and are based on a combination of an immunocytokine with an immunocytokine uptake enhancing agent. Disclosed methods and compositions are particularly useful for reducing tumor size and metastasis in a mammal.
(FR)La présente invention concerne des méthodes et des compositions destinées à la cancérothérapie. Ces méthodes et ces compositions améliorent la fixation des immunocytokines sur les tumeurs, et reposent sur une association d'immunocytokines et d'agent améliorant la fixation des immunocytokines. Ces méthodes et ces compositions sont particulièrement utiles dans la réduction de la taille des tumeurs et des métastases chez les mammifères.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)