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1. WO2002001647 - MICROELECTRONIC DEVICE AND METHOD FOR LABEL-FREE DETECTION AND QUANTIFICATION OF BIOLOGICAL AND CHEMICAL MOLECULES

Publication Number WO/2002/001647
Publication Date 03.01.2002
International Application No. PCT/US2001/020052
International Filing Date 22.06.2001
Chapter 2 Demand Filed 22.06.2001
IPC
G01N 27/414 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
27Investigating or analysing materials by the use of electric, electro-chemical, or magnetic means
26by investigating electrochemical variables; by using electrolysis or electrophoresis
403Cells and electrode assemblies
414Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
G01N 33/543 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
543with an insoluble carrier for immobilising immunochemicals
CPC
G01N 27/4145
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
27Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
26by investigating electrochemical variables; by using electrolysis or electrophoresis
403Cells and electrode assemblies
414Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
4145specially adapted for biomolecules, e.g. gate electrode with immobilised receptors
G01N 33/54373
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
543with an insoluble carrier for immobilising immunochemicals
54366Apparatus specially adapted for solid-phase testing
54373involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
H01L 2924/0002
HELECTRICITY
01BASIC ELECTRIC ELEMENTS
LSEMICONDUCTOR DEVICES; ELECTRIC SOLID STATE DEVICES NOT OTHERWISE PROVIDED FOR
2924Indexing scheme for arrangements or methods for connecting or disconnecting semiconductor or solid-state bodies as covered by H01L24/00
0001Technical content checked by a classifier
0002Not covered by any one of groups H01L24/00, H01L24/00 and H01L2224/00
Applicants
  • THE UNITED STATES OF AMERICA, as represented by THE SECRETARY OF THE NAVY [US]/[US]
Inventors
  • TENDER, Leonard, M.
  • PECKERAR, Martin
  • PERKINS, F. Keith
  • FERTIG, Stephanie, J.
  • SNOW, Eric, S.
Agents
  • KARASEK, John, J.
Priority Data
60/213,47123.06.2000US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) MICROELECTRONIC DEVICE AND METHOD FOR LABEL-FREE DETECTION AND QUANTIFICATION OF BIOLOGICAL AND CHEMICAL MOLECULES
(FR) DISPOSITIF MICRO-ELECTRONIQUE ET PROCEDE DE DETECTION ET DE QUANTIFICATION SANS MARQUEUR DE MOLECULES BIOLOGIQUES ET CHIMIQUES
Abstract
(EN) Molecular recognition-based electronic sensor, which is gateless, depletion mode field effect transistor consisting of source (12) and drain (14) diffusions, a depletion-mode implant, and insulating layer chemically modified by immobilized molecular receptors (100) that enables miniaturized label-free molecular detection amenable to high-density array formats. The conductivity of the active channel (20) modulates current flow through the active channel (20) when a voltage is applied between the source (12) and drain (14) diffusions. The conductivity of the active channel (20) is determined by the potential of the sample solution (90) in which the device is immersed and the device-solution interfacial capacitance. The conductivity of the active channel (20) modulates current flow through the active channel (20) when a voltage is applied between the source (12) and drain (14) diffusions. The interfacial capacitance is determined by the extent of occupancy of the immobilized receptor molecules by target molecules. Target molecules can be either charged or uncharged. Change in interfacial capacitance upon target molecule binding results in modulation of an externally supplied current through the channel.
(FR) La présente invention concerne un capteur électronique de reconnaissance moléculaire, sans grille, comportant un transistor à effet de champ fonctionnant en mode de déplétion qui comprend des diffusions de source (12) et de drain (14), un implant fonctionnant en mode de déplétion, et une couche isolante modifiée chimiquement par des récepteurs moléculaires immobilisés (100) qui permet la détection moléculaire miniaturisée sans marqueur par des formats de matrices haute densité. La conductivité du canal actif (20) module l'écoulement du courant dans le canal actif (20) lorsqu'une une tension est appliquée entre les diffusions de source (12) et de drain (14). La conductivité du canal actif (20) est déterminée par le potentiel de la solution (90) d'échantillon dans laquelle le dispositif est immergé et par la capacité interfaciale de la solution du dispositif. La conductivité du canal actif (20) module le flux de courant qui traverse le canal actif (20) lorsqu'une tension est appliquée entre les diffusions de source (12) et de drain (14). La capacité interfaciale est déterminée par le degré d'occupation des molécules des récepteurs immobilisés par les molécules cibles. Les molécules cibles peuvent être soit chargées soit non chargées. Le changement de la capacité interfaciale consécutif à la liaison des molécules cibles entraîne la modulation d'un courant fourni extérieurement dans ledit canal.
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