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1. (WO2002000885) ASSEMBLY OF WILD-TYPE AND CHIMERIC INFLUENZA VIRUS-LIKE PARTICLES (VLPS)
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2002/000885    International Application No.:    PCT/US2001/019890
Publication Date: 03.01.2002 International Filing Date: 21.06.2001
Chapter 2 Demand Filed:    17.01.2002    
IPC:
C07K 14/11 (2006.01), C12N 7/04 (2006.01)
Applicants: AMERICAN CYANAMID COMPANY [US/US]; 5 Giralda Farms, Madison, NJ 07940 (US) (For All Designated States Except US).
GALARZA, Jose, M. [AR/US]; (US) (For US Only).
LATHAM, Theresa, E. [US/US]; (US) (For US Only)
Inventors: GALARZA, Jose, M.; (US).
LATHAM, Theresa, E.; (US)
Agent: GORDON, Alan, M.; American Home Products Corporation, Patent Law Department, 5 Giralda Farms, Madison, NJ 07940 (US).
WILEMAN, david Francis; Wyeth Laboratories, Huntercombe Lane South, Taplow, Maidenhead, Berkshire SL6 OPH (GB)
Priority Data:
60/213,656 23.06.2000 US
60/284,411 17.04.2001 US
Title (EN) ASSEMBLY OF WILD-TYPE AND CHIMERIC INFLUENZA VIRUS-LIKE PARTICLES (VLPS)
(FR) ASSEMBLAGE SAUVAGE-CHIMERIQUE DE PARTICULES VIRALOÏDES DE LA GRIPPE (VLP)
Abstract: front page image
(EN)Influenza virus-like particles (VLPs) comprising the structural proteins HA, NA, M1 and M2 are described. VLPs are also generated containing M1 alone, as are VLPs with M1 and any one or two of HA, Na and M2. VLPs with HA from one influenza subtype and NA from a different influenza subtype are also described, as are VLPs in which a portion or all of HA or NA is replaced by a heterologous moiety not produced by influenza virus, so as to comprise chimeric VLPs.
(FR)La présente invention concerne des particules viraloïdes (VLP) de la grippe comprenant les protéines structurelles HA, NA, M1 et M2. On a également généré des VLP contenant la MA seule, ainsi que des VLP avec la M1 et une ou deux des protéines HA, NA, et M2. L'invention concerne également des VLP avec une HA d'un sous-type de la grippe, et une NA d'un sous-type différent de la grippe, mais aussi des VLP dans lesquelles tout ou partie des HA et NA est remplacé par un fragment hétérologue non produit par le virus de la grippe, de façon à englober les VLP chimériques.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)