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1. WO2002000708 - MUTANTS OF PROSTASE

Publication Number WO/2002/000708
Publication Date 03.01.2002
International Application No. PCT/EP2001/007079
International Filing Date 21.06.2001
Chapter 2 Demand Filed 19.12.2001
IPC
A61K 39/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
C12N 9/64 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
14Hydrolases (3.)
48acting on peptide bonds, e.g. thromboplastin, leucine aminopeptidase (3.4)
50Proteinases
64derived from animal tissue, e.g. rennin
CPC
A61K 39/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
A61P 13/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
08of the prostate
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07K 2319/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2319Fusion polypeptide
C12N 9/6445
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes; Proenzymes; Compositions thereof
14Hydrolases (3)
48acting on peptide bonds (3.4)
50Proteinases ; , e.g. Endopeptidases (3.4.21-3.4.25)
64derived from animal tissue
6421from mammals
6424Serine endopeptidases (3.4.21)
6445Kallikreins (3.4.21.34; 3.4.21.35)
Applicants
  • SMITHKLINE BEECHAM BIOLOGICALS S.A. [BE]/[BE] (AllExceptUS)
  • CABEZON SILVA, Teresa, Elisa, Virginia [BE]/[BE] (UsOnly)
  • MARCHAND, Martine [BE]/[BE] (UsOnly)
  • VINALS Y DE BASSOLS, Carlota [BE]/[BE] (UsOnly)
Inventors
  • CABEZON SILVA, Teresa, Elisa, Virginia
  • MARCHAND, Martine
  • VINALS Y DE BASSOLS, Carlota
Agents
  • DALTON, Marcus, Jonathan, William
Priority Data
0015736.227.06.2000GB
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) MUTANTS OF PROSTASE
(FR) VACCIN
Abstract
(EN) The present invention relates to novel proteins and to their production, from the prostase family. In particular, the invention relates to a genetically modified prostase wherein the protein is mutated in its active site. Such antigens may be formulated to provide vaccines for the treatment of prostate tumours. Methods for purifying prostase protein and homologues are also provided.
(FR) La présente invention concerne de nouvelles protéines et leur production, à partir de la famille de la prostase. En particulier, l'invention concerne une prostase génétiquement modifiée selon laquelle la protéine a subi une mutation dans son site actif. De tels antigènes peuvent être formulés pour produire des vaccins pour traiter les tumeurs de la prostate. L'invention traite également de procédés pour purifier la protéine de la prostase et ses homologues.
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