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1. WO2002000684 - METHOD OF OBTAINING PEPTIDES WITH TISSUE-SPECIFIC ACTIVITY AND PHARMACEUTICAL COMPOSITIONS ON THEIR BASIS

Publication Number WO/2002/000684
Publication Date 03.01.2002
International Application No. PCT/RU2001/000256
International Filing Date 26.06.2001
Chapter 2 Demand Filed 19.01.2002
IPC
A61K 38/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 1/12 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
1General processes for the preparation of peptides
12by hydrolysis
C07K 5/103 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
10Tetrapeptides
103the side chain of the first amino acid being acyclic, e.g. Gly, Ala
C07K 5/11 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
10Tetrapeptides
11the side chain of the first amino acid containing more amino groups than carboxyl groups, or derivatives thereof, e.g. Lys, Arg
C07K 14/47 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61P 1/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
16for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
A61P 25/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
C07K 14/47
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
C07K 5/1008
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
10Tetrapeptides
1002with the first amino acid being neutral
1005and aliphatic
1008the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
Applicants
  • SANKT-PETERBURGSKAYA OBSCHESTVENNAYA OGRANIZATSIYA 'INSTITUT BIOREGULYATSII I GERONTOLOGII CZO RAMN' [RU]/[RU] (AllExceptUS)
  • KHAVINSON, Vladimir Khatskelevich [RU]/[RU] (UsOnly)
Inventors
  • KHAVINSON, Vladimir Khatskelevich
Agents
  • SANKT-PETERBURGSKAYA OBSCHESTVENNAYA OGRANIZATSIYA 'INSTITUT BIOREGULYATSII I GERONTOLOGII CZO RAMN'
Priority Data
200011679129.06.2000RU
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) METHOD OF OBTAINING PEPTIDES WITH TISSUE-SPECIFIC ACTIVITY AND PHARMACEUTICAL COMPOSITIONS ON THEIR BASIS
(FR) PROCEDE DE FABRICATION DE PEPTIDES A ACTIVITE SPECIFIQUE AUX TISSUS ET COMPOSITIONS PHARMACEUTIQUES A BASE DE CEUX-CI
Abstract
(EN) The invention refers to the field of chemistry and concerns the method of obtaining peptides with tissue-specific activity by targeted chemical synthesis. This invention can be employed in medicine to obtain peptide-based pharmaceuticals normalising the functions of various organs and functions. The method of obtaining peptides proposed in this patent claim embraces quantitative amino acid analysis of acetic extracts from tissues, selection on its basis of two amino acids (Glu and Asp) prevailing in the studied tissue, synthesis of the central link from these amino acids and attachment to its N- and C-ends of the amino acids prevailing among the remaining amino acids in the studied tissue. The peptides obtained by the claimed method possess a tissue-specific activity. There is proposed a pharmaceutical composition possessing a tissue-specific activity and containing as its active base one of the peptides obtained by the claimed method or its salts and a pharmaceutically admissible carrier.
(FR) L'invention appartient au domaine de la chimie et concerne un procédé de fabrication de peptides à activité spécifique aux tissus par synthèse chimique ciblée. L'invention peut s'utiliser en médecine dans la fabrication de produits pharmaceutiques à base de peptides qui normalisent les fonctions de divers organes et fonctions. Le procédé de fabrication de peptides proposé dans l'invention englobe l'analyse quantitative des acides aminés d'extraits acétiques provenant des tissus, la sélection sur cette base de deux acides aminés (Glu et Asp) prédominants dans le tissu étudié, la synthèse de la liaison centrale à partir de ces acides aminés et l'attachement à leurs extrémités N- et C- des acides aminés prédominant parmi les acides aminés dans le tissu étudié. Les peptides obtenus par le procédé de l'invention ont une activité spécifique aux tissus. L'invention concerne aussi une composition pharmaceutique manifestant une activité spécifique aux tissus et contenant en tant que principe actif un des peptides obtenus par le procédé de l'invention et un excipient pharmaceutiquement acceptable.
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