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1. WO2002000664 - 2-AMINOALKYL-THIENO[2,3-D]PYRIMIDINES

Publication Number WO/2002/000664
Publication Date 03.01.2002
International Application No. PCT/EP2001/007379
International Filing Date 28.06.2001
Chapter 2 Demand Filed 28.01.2002
IPC
C07D 495/04 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
495Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
CPC
A61P 15/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
15Drugs for genital or sexual disorders
10for impotence
A61P 21/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
21Drugs for disorders of the muscular or neuromuscular system
A61P 29/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or anti-inflammatory agents, e.g antirheumatic agents; Non-steroidal anti-inflammatory drugs (NSAIDs)
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
A61P 9/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
A61P 9/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
10for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Applicants
  • MERCK PATENT GMBH [DE]/[DE] (AllExceptUS)
  • JONAS, Rochus [DE]/[DE] (UsOnly)
  • SCHELLING, Pierre [CH]/[DE] (UsOnly)
  • CHRISTADLER, Maria [DE]/[DE] (UsOnly)
  • BEIER, Norbert [DE]/[DE] (UsOnly)
Inventors
  • JONAS, Rochus
  • SCHELLING, Pierre
  • CHRISTADLER, Maria
  • BEIER, Norbert
Agents
  • ISENBRUCK, Günter
Priority Data
100 31 585.229.06.2000DE
Publication Language German (de)
Filing Language German (DE)
Designated States
Title
(DE) 2-AMINOALKYL-THIENO[2,3-D]PYRIMIDINE
(EN) 2-AMINOALKYL-THIENO[2,3-D]PYRIMIDINES
(FR) 2-AMINOALKYL-THIENO[2,3-D]PYRIMIDINES
Abstract
(DE) Die vorliegende Erfindung betrifft 2 Aminomethyl-thieno[2,3-d]pyrimidine der allgemeinen Formel (I) in der die Reste R1 bis R6 die im Text angegebene Bedeutung haben. Die Verbindungen zeigen eine Phosphodiesterase V-Hemmung und können zur Behandlung von Erkrankungen des Herz-Kreislaufsystems und zur Behandlung von Potenzstörungen eingesetzt werden.
(EN) The invention relates to 2 aminomethyl-thieno[2,3-d]pyrimidines of general formula (I), wherein the radicals R1 to R6 have the meanings given in the text. These compounds demonstrate phosphodiesterase V inhibition and can be used to treat diseases of the cardiovascular system and potency disorders.
(FR) L'invention concerne des 2-aminométhyl-thiéno[2,3-d]pyrimidines de formule générale (I) dans laquelle les restes R1 à R6 ont la signification mentionnée dans le texte. Ces composés exercent une inhibition de la phosphodiestérase V et s'utilisent pour traiter des affections du système cardio-vasculaire, ainsi que des troubles de l'érection.
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