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1. (WO2002000648) IMIDAZOLE DERIVATIVES OR SALTS THEREOF AND DRUGS CONTAINING THE DERIVATIVES OR THE SALTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2002/000648    International Application No.:    PCT/JP2001/004836
Publication Date: 03.01.2002 International Filing Date: 08.06.2001
Chapter 2 Demand Filed:    04.12.2001    
IPC:
C07D 233/22 (2006.01), C07D 401/12 (2006.01), C07D 401/14 (2006.01), C07D 403/12 (2006.01), C07D 405/14 (2006.01), C07D 409/14 (2006.01), C07D 521/00 (2006.01)
Applicants: SSP CO., LTD. [JP/JP]; 2-12-4, NIHONBASHIHAMACHO CHUO-KU, Tokyo 103-8481 (JP) (For All Designated States Except US).
KONNO, Fujiko [JP/JP]; (JP) (For US Only).
NAGAO, Yoshihiro [JP/JP]; (JP) (For US Only).
ISOMAE, Kazuo [JP/JP]; (JP) (For US Only).
OHTSUKA, Mari [JP/JP]; (JP) (For US Only).
TAKAHASHI, Yoshiyuki [JP/JP]; (JP) (For US Only).
ISHII, Fumio [JP/JP]; (JP) (For US Only).
HIROTA, Hiroyuki [JP/JP]; (JP) (For US Only).
TAKEDA, Sunao [JP/JP]; (JP) (For US Only).
KAWAMOTO, Noriyuki [JP/JP]; (JP) (For US Only).
HONDA, Haruyoshi [JP/JP]; (JP) (For US Only).
SATO, Susumu [JP/JP]; (JP) (For US Only)
Inventors: KONNO, Fujiko; (JP).
NAGAO, Yoshihiro; (JP).
ISOMAE, Kazuo; (JP).
OHTSUKA, Mari; (JP).
TAKAHASHI, Yoshiyuki; (JP).
ISHII, Fumio; (JP).
HIROTA, Hiroyuki; (JP).
TAKEDA, Sunao; (JP).
KAWAMOTO, Noriyuki; (JP).
HONDA, Haruyoshi; (JP).
SATO, Susumu; (JP)
Agent: ARUGA, Mitsuyuki; KYODO BLDG., 3-6, NIHONBASHININGYOCHO 1-CHOME CHUO-KU, Tokyo 103-0013 (JP)
Priority Data:
2000-194024 28.06.2000 JP
Title (EN) IMIDAZOLE DERIVATIVES OR SALTS THEREOF AND DRUGS CONTAINING THE DERIVATIVES OR THE SALTS
(FR) DERIVES IMIDAZOLE OU SELS DE CES DERNIERS, ET MEDICAMENTS CONTENANT LES DERIVES OU LES SELS
Abstract: front page image
(EN)Imidazole derivatives of the general formula (1) or salts thereof; and drugs containing the derivatives or the salts as the active ingredient wherein R?1¿ and R?2¿ are each aryl, heteroaryl, or the like; A, X?1¿ and X?2¿ are each N or CH; Y and Z are each O, S, or the like; R?3¿, R?4¿ and R?5¿ are each hydrogen, alkyl, or the like; m is a number of 1 to 4; and n is a number of 0 to 4. These compounds exhibit excellent inhibitory activities against the production of NO and IL-6 and are useful in the prevention or treatment of diseases resulting from overdevelopment of NO and IL-6.
(FR)L'invention concerne des dérivés imidazole de formule générale (I) ou des sels de ces derniers, ainsi que des médicaments contenant comme principe actif lesdits dérivés ou lesdits sels, formule (I) dans laquelle R1 et R2 représentent tous deux aryle, hétéroaryle ou similaire; A, X1 et X2 représente chacun N ou CH ; Y et Z représentent chacun O, S ou similaire ; R3, R4 et R5 représentent chacun hydrogène, alkyle ou similaire ; m est un nombre compris entre 1 et 4 et n est un nombre compris entre 0 et 4. Ces composés présentent une excellente activité inhibitrice de la production de NO et d'IL-6 et sont très utiles dans la prévention ou le traitement de maladies induites par un développement exagéré de NO et d'IL-6.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)