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1. (WO2002000611) FMOC-L-LEUCINE AND DERIVATIVES THEREOF AS PPAR-GAMMA AGONISTS

Pub. No.:    WO/2002/000611    International Application No.:    PCT/IB2001/001581
Publication Date: Jan 3, 2002 International Filing Date: Jun 28, 2001
IPC: A61K 31/325
C07C 271/22
Applicants: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
ROCCHI, Stéphane
AUWERX, Johan
VAMECQ, Joseph
Inventors: ROCCHI, Stéphane
AUWERX, Johan
VAMECQ, Joseph
Title: FMOC-L-LEUCINE AND DERIVATIVES THEREOF AS PPAR-GAMMA AGONISTS
Abstract:
The present invention relates to a method for treating or preventing a PPAR-η mediated disease or condition comprising administration of a therapeutically effective amount of FMOC-L-Leucine or derivatives thereof, of the formula I: Said method is particularly useful for treating or preventing anorexia, hyperlypidemia, insulin resistance, inflammatory diseases, cancer and sking disorders.