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1. (WO2001091740) COMPOSITIONS CONTAINING NAPHTHAQUINONE AND AN ANTIPROLIFERATIVE AGENT
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2001/091740 International Application No.: PCT/US2001/017677
Publication Date: 06.12.2001 International Filing Date: 01.06.2001
Chapter 2 Demand Filed: 22.12.2001
IPC:
A61K 31/122 (2006.01) ,A61K 31/7064 (2006.01) ,A61K 31/7076 (2006.01) ,A61K 33/24 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
12
Ketones
122
having the oxygen atom directly attached to a ring, e.g. quinones, vitamin K1, anthralin
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7042
Compounds having saccharide radicals and heterocyclic rings
7052
having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
706
containing six-membered rings with nitrogen as a ring hetero atom
7064
containing condensed or non-condensed pyrimidines
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7042
Compounds having saccharide radicals and heterocyclic rings
7052
having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
706
containing six-membered rings with nitrogen as a ring hetero atom
7064
containing condensed or non-condensed pyrimidines
7076
containing purines, e.g. adenosine, adenylic acid
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
33
Medicinal preparations containing inorganic active ingredients
24
Heavy metals; Compounds thereof
Applicants:
BROWN, Dennis, M. [US/US]; US (UsOnly)
CHEMGENEX THERAPEUTICS, INC. [US/US]; Suite M 3475 Edison Way Menlo Park, CA 94025, US (AllExceptUS)
Inventors:
BROWN, Dennis, M.; US
Agent:
TRECARTIN, Richard, F. ; Flehr, Hohbach, Test, Albritton & Herbert LLP 4 Embarcadero Center, Suite 3400 San Francisco, CA 94111-4187, US
Priority Data:
60/208,64501.06.2000US
Title (EN) COMPOSITIONS CONTAINING NAPHTHAQUINONE AND AN ANTIPROLIFERATIVE AGENT
(FR) COMPOSITIONS DE NAPHTHOQUINONE ET UTILISATIONS DE CELLES-CI
Abstract:
(EN) A method of treatment of a host with a cellular proliferative disease, comprising contacting the host with a naphthoquinone and an antiproliferative agent, each in an amount sufficient to modulate said cellular proliferative disease, is described. In some embodiments, the naphthoquinone comprises menadione (Kativ-G; 2-Methyl-1,4-Naphthoquinone; Menaphthone; Vitamin K3; Panosine; 2-Methyl-1,4-naphthalenedione; Vitamin K2(0); Methyl-1,4-naphthalenedione; Methyl-1,4-naphthoquinone). Antiproliferative agents of the invention comprise alkylating agents, intercalating agents, metal coordination complexes, pyrimidine nucleosides, purine nucleosides, inhibitors of nucleic acid associated enzymes and proteins, and agents affecting structural proteins and cytoplasmic enzymes. The invention comprises the described methods as well as compositions comprising a naphthoquinine and an antiproliferative agent.
(FR) L'invention concerne une méthode permettant de traiter un hôte atteint d'une maladie proliférative cellulaire. Cette méthode consiste à mettre en contact l'hôte avec un naphthoquinone et un agent antiprolifératif, chacun en quantité suffisante pour moduler ladite maladie proliférative cellulaire. Dans certains modes de réalisation, le naphthoquinone comprend du ménadione (Kativ-G; 2-Méthyl-1,4-Naphthoquinone; Ménaphthone; Vitamine K3; Panosine; 2-Méthyl-1,4-naphthalènedione; Vitamine K2(0); Méthyl-1,4-naphthalènedione; Méthyl-1,4-naphthoquinone). Les agents antiprolifératifs décrits dans cette invention incluent des d'agents d'alkylation, des complexes de coordination métalliques, des nucléosides de pyrimidine, des nucléosides de purine, des inhibiteurs d'enzymes associées aux acides nucléiques et des protéines, et des agents affectant les protéines structurales et des enzymes cytoplasmiques. L'invention concerne également des méthodes et des compositions contenant un naphthoquinone et un agent antiprolifératif.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)