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1. (WO2001090420) DRUG-OLIGONUCLEOTIDES CHIMERIC MOLECULES

Pub. No.:    WO/2001/090420    International Application No.:    PCT/US2001/017125
Publication Date: Nov 29, 2001 International Filing Date: May 25, 2001
IPC: C07B 61/00
C07H 21/00
C07K 1/04
C12N 15/10
Applicants: EVORX
NATHAN, Asher
Inventors: NATHAN, Asher
Title: DRUG-OLIGONUCLEOTIDES CHIMERIC MOLECULES
Abstract:
The present invention relates to methods of increasing the efficacy of existing drugs, and more particularly relates to modifying known drugs by combining them with obligonucleotides to produce chimeric drug-oligonucleotide molecules having superior targeting,uptake and retention than the unmodified known drug.