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Machine translation
1. (WO2001090186) METHODS FOR IDENTIFYING MODULATORS OF THE INTERACTION BETWEEN LAP (LATENCY ASSOCIATED PEPTIDE) AND INTERGRIN ALPHA.V.BETA.3 AND MEDICAL USE THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2001/090186    International Application No.:    PCT/GB2001/002352
Publication Date: 29.11.2001 International Filing Date: 25.05.2001
Chapter 2 Demand Filed:    26.11.2001    
IPC:
A61K 38/17 (2006.01)
Applicants: GLAXO GROUP LIMITED [GB/GB]; Glaxo Wellcome House Berkeley Avenue Greenford Middlesex UB6 ONN (GB) (For All Designated States Except US).
LUDBROOK, Steven [GB/GB]; (GB) (For US Only).
BARRY, Simon [GB/GB]; (GB) (For US Only).
HORGAN, Carmel [GB/GB]; (GB) (For US Only).
MILLER, David [GB/GB]; (GB) (For US Only)
Inventors: LUDBROOK, Steven; (GB).
BARRY, Simon; (GB).
HORGAN, Carmel; (GB).
MILLER, David; (GB)
Agent: WOODS, Geoffrey, Corlett; J.A. Kemp & Co. 14 South Square Gray's Inn London WC1R 5LX (GB)
Priority Data:
0012991.6 26.05.2000 GB
0100286.4 05.01.2001 GB
Title (EN) METHODS FOR IDENTIFYING MODULATORS OF THE INTERACTION BETWEEN LAP (LATENCY ASSOCIATED PEPTIDE) AND INTERGRIN ALPHA.V.BETA.3 AND MEDICAL USE THEREOF
(FR) PROCEDES POUR IDENTIFIER LES MODULATEURS DE L'INTERACTION ENTRE LAP (PEPTIDE ASSOCIE A LA LATENCE) ET L'INTEGRINE ALPHA.V.BETA.3 AINSI QUE LEUR UTILISATION MEDICALE
Abstract: front page image
(EN)A method for the identification of a modulator of the interaction between latency associated peptide (LAP) of transforming growth factor $g(b)1 (TGF-$g(b)1) and the integrin a¿v?b¿3?, which method comprises: (a) providing, as a first component, LAP-$g(b)1 or a functional variant thereof; (b) providing, as a second component, integrin a¿v?b¿3? or a functional variant thereof; (c) contacting the two components with a test product under conditions that, in the absence of the test product, would permit the two components to interact; and (d) determining whether the test product is capable of modulating the interaction between the first and second components, thereby to determine whether the test product is a modulator of the interaction between LAP-$g(b)1 and integrin a¿v?b¿3?.
(FR)Procédé destiné à l'identification d'un modulateur de l'interaction entre le peptide associé à la latence (LAP) du facteur de croissance transformant $g(b) 1 (TGF-$g(b) 1) et l'intégrine avb3, le procédé comprenant ce qui suit: (a) fournir en tant que premier composant LAP-$g(b)1 ou une variante fonctionnelle de celui-ci; (b) fournir en tant que deuxième composant l'intégrine avb3 ou une variante fonctionnelle de celle-ci; (c) mettre les deux composants en contact avec un produit de test dans des conditions qui, en absence du produit test, permettraient aux deux composants d'interagir; et (d) déterminer si le produit test est capable de moduler l'interaction entre les premier et second composants et déterminer ainsi si le produit test est un modulateur de l'interaction entre LAP-$g(b)1 et l'intégrine avb3.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)