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1. (WO2001090163) USE OF THE GABAB RECEPTOR IN ASSAYS TO IDENTIFY GAMMA HYDROXYBUTYRATE AGONISTS, ANTAGONISTS, AND ALLOSTERIC MODULATORS OF AGONISTS

Pub. No.:    WO/2001/090163    International Application No.:    PCT/CA2001/000770
Publication Date: Nov 29, 2001 International Filing Date: May 24, 2001
IPC: C07K 14/705
G01N 33/94
Applicants: MERCK FROSST CANADA & CO.
NG, Gordon, Yiu, Kon
Inventors: NG, Gordon, Yiu, Kon
Title: USE OF THE GABAB RECEPTOR IN ASSAYS TO IDENTIFY GAMMA HYDROXYBUTYRATE AGONISTS, ANTAGONISTS, AND ALLOSTERIC MODULATORS OF AGONISTS
Abstract:
An unexpected and novel mechanism of action for gamma hydroxybutyrate (GHB) has been discovered: agonist activity at the functional GABAB receptor. The discovery of this mechanism of action allows for the development of assays for the identification of modulators, such as agonists and antagonists, of GHB.