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1. (WO2001090159) COMPOSITIONS AND METHODS FOR DELIVERY OF A MOLECULE INTO A CELL

Pub. No.:    WO/2001/090159    International Application No.:    PCT/US2001/016943
Publication Date: Nov 29, 2001 International Filing Date: May 23, 2001
IPC: A61K 38/16
A61K 41/00
A61K 47/48
C07K 14/16
C12N 15/87
Applicants: THE J. DAVID GLADSTONE INSTITUTES
SCHUBERT, Ulrich
HENKLEIN, Peter
Inventors: SCHUBERT, Ulrich
HENKLEIN, Peter
SHERMAN, Michael, P.
GREENE, Warner, C.
DE NORONHA, Carlos, M., C.
Title: COMPOSITIONS AND METHODS FOR DELIVERY OF A MOLECULE INTO A CELL
Abstract:
Provided is a composition comprising a Vpr polypeptide conjugated to a therapeutic molecule. Preferably, the Vpr comprises synthetic Vpr. The therapeutic molecule can comprise any molecule capable of being conjugated to Vpr or a fragment thereof, including a polypeptide, a polynucleotide, and/or a toxin. The invention additionally provides a method for delivering a molecule into a cell. The method comprises contacting the cell with a conjugate comprising a Vpr polypeptide conjugated to the molecule. The invention further provides a method for modulating the expression of a transgene in a cell, a method for killing a target cell population in a subject, a method for increasing the sensitivity of cells to radiation therapy, and a method for inhibiting cell proliferation.