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1. (WO2001090109) HETEROARYLDIAZABICYCLOALKANES AS NICOTINIC CHOLINERGIC RECEPTOR LIGANDS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2001/090109    International Application No.:    PCT/US2001/016941
Publication Date: 29.11.2001 International Filing Date: 24.05.2001
Chapter 2 Demand Filed:    17.12.2001    
IPC:
C07D 487/08 (2006.01)
Applicants: TARGACEPT, INC. [US/US]; 950 Reynolds Boulevard Winston-Salem, NC 27102 (US) (For All Designated States Except US).
MILLER, Craig, Harrison [US/US]; (US) (For US Only).
DULL, Gary, Maurice [US/US]; (US) (For US Only).
MIAO, Lan [US/US]; (US) (For US Only).
LYNM, Dwo [US/US]; (US) (For US Only).
SCHMITT, Jeffrey, Daniel [US/US]; (US) (For US Only).
CLARK, Thomas, Jeffrey [US/US]; (US) (For US Only)
Inventors: MILLER, Craig, Harrison; (US).
DULL, Gary, Maurice; (US).
MIAO, Lan; (US).
LYNM, Dwo; (US).
SCHMITT, Jeffrey, Daniel; (US).
CLARK, Thomas, Jeffrey; (US)
Agent: WOMBLE CARYLE SANDRIDGE & RICE, PLLC; P.O. Box 7037 Atlanta, GA 30357-0037 (US)
Priority Data:
09/578,768 25.05.2000 US
09/864,905 24.05.2001 US
Title (EN) HETEROARYLDIAZABICYCLOALKANES AS NICOTINIC CHOLINERGIC RECEPTOR LIGANDS
(FR) HETEROARYLDIAZABICYCLOALKANES COMME LIGANDS DU RECEPTEUR CHOLINERGIQUE NICOTINIQUE
Abstract: front page image
(EN)The present invention relates to diazabicyclic compounds, preferably to N-aryl diazabicyclic compounds. Of particular interest are 2-pyridyl diazabicyclic compounds, such as (1S,4S)-2-(5-(3-methoxyphenoxy)-3-pyridyl)-2,5-diazabicyclo[2.2.1]heptane. Other exemplary compounds of the present invention include: (1S,4S)-2-(5-(4-methoxyphenoxy)-3-pyridyl)-2,5-diazabicyclo[2.2.1]heptane, (1S,4S)-2-(5-(3,4-dimethoxyphenoxy)-3-pyridyl)-2,5-diazabicyclo[2.2.1]heptane, (1S,4S)-2-(5-(4-fluorophenoxy)-3-pyridyl)-2,5-diazabicyclo[2.2.1]heptane, and (1S,4S)-2-(5-benzoyl-3-pyridyl)-2,5-diazabicyclo[2.2.1]heptane. The present invention also relates to prodrug derivatives of the compounds of the present invention.
(FR)La présente invention concerne des composés diazabicycliques, de préférence, des composés diazabicycliques de N-aryle. Des composés particulièrement intéressants sont les composés de 2-pyridyle diazabicyclique comme (1S,4S)-2-(5-(3-méthoxyphénoxy)-3-pyridyl)-2,5-diazabicyclo[2.2.1]heptane. D'autres composés représentant des exemples de la présente invention comprennent: (1S,4S)-2-(5-(4-méthoxyphénoxy)-3-pyridyl)-2,5-diazabicyclo[2.2.1]heptane, (1S,4S)-2-(5-(3,4-diméthoxyphénoxy)-3-pyridyl)-2,5-diazabicyclo[2.2.1]heptane, (1S,4S)-2-(5-(4-fluorophénoxy)-3-pyridyl)-2,5-diazabicyclo[2.2.1]heptane, et (1S,4S)-2-(5-benzoyl-3-pyridyl)-2,5-diazabicyclo[2.2.1]heptane. La présente invention concerne également des dérivés des composés de la présente invention constituant des promédicaments.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)