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1. (WO2001090103) 3-(PYRROL-2-YLMETHYLIDENE)-2-INDOLINONE DERIVATIVES AND THEIR USE AS PROTEIN KINASE MODULATORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2001/090103    International Application No.:    PCT/US2001/016741
Publication Date: 29.11.2001 International Filing Date: 24.05.2001
Chapter 2 Demand Filed:    20.12.2001    
IPC:
C07D 403/06 (2006.01), C07D 403/14 (2006.01), C07F 9/572 (2006.01), C07F 9/6558 (2006.01)
Applicants: SUGEN, INC. [US/US]; 230 East Grand Avenue South San Francisco, CA 94080 (US) (For All Designated States Except US).
PHARMACIA & UPJOHN COMPANY [US/US]; 301 Henrietta Street Kalamazoo, MI 49001 (US) (For All Designated States Except US).
MOON, Malcolm, Wilson [US/US]; (US) (For US Only).
MOROZOWICH, Walter [US/US]; (US) (For US Only).
GAO, Ping [CN/US]; (US) (For US Only).
KOENIG, Marcel [CH/US]; (US) (For US Only)
Inventors: MOON, Malcolm, Wilson; (US).
MOROZOWICH, Walter; (US).
GAO, Ping; (US).
KOENIG, Marcel; (US)
Agent: BURROUS, Beth, A.; Foley & Lardner Washington Harbour Suite 500 3000 K Street, N.W. Washington, DC 20007-5109 (US)
Priority Data:
60/207,000 24.05.2000 US
60/225,045 11.08.2000 US
Title (EN) 3-(PYRROL-2-YLMETHYLIDENE)-2-INDOLINONE DERIVATIVES AND THEIR USE AS PROTEIN KINASE MODULATORS
(FR) PROMEDICAMENTS DE DERIVES DE 3-(PYRROL-2-YL-METHYLIDENE)-2-INDOLINONE
Abstract: front page image
(EN)The present invention is directed to prodrugs of certain 3-(pyrrol-2-yl-methylidene)-2-indolinone derivatives that modulate the activity of protein kinases ('PKs'). Pharmaceutical compositions comprising these compounds, methods of treating diseases related to abnormal PK activity utilizing pharmaceutical compositions comprising these compounds and methods of preparing them are also disclosed.
(FR)L'invention concerne des promédicaments de certains dérivés de 3-(pyrrol-2-yl-méthylidène)-2-indolinone qui modulent l'activité de protéines kinases (PK). L'invention concerne également des compositions pharmaceutiques qui contiennent ces composés, des méthodes de traitement de maladies liées à une activité anormale de PK, utilisant lesdites compositions, ainsi que des procédés de préparation de ces dernières.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)