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Machine translation
1. (WO2001090068) MANNICH BASE PRODRUGS OF 3-(PYRROL-2-YLMETHYLIDENE)-2-INDOLINONE DERIVATIVES AND THEIR USE A MODULATORS OF PROTEIN KINASES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2001/090068    International Application No.:    PCT/US2001/016757
Publication Date: 29.11.2001 International Filing Date: 24.05.2001
Chapter 2 Demand Filed:    20.12.2001    
IPC:
C07D 403/06 (2006.01), C07D 403/14 (2006.01), C07F 9/572 (2006.01), C07F 9/6558 (2006.01)
Applicants: SUGEN, INC. [US/US]; 230 East Grand Avenue South San Francisco, CA 94080-4811 (US) (For All Designated States Except US).
PHARMACIA & UPJOHN COMPANY [US/US]; 301 Henrietta Street Kalamazoo, MI 49001 (US) (For All Designated States Except US).
MOON, Malcolm, Wilson [US/US]; (US) (For US Only).
MOROZOWICH, Walter [US/US]; (US) (For US Only).
GAO, Ping [CN/US]; (US) (For US Only).
TANG, Peng, Cho [US/US]; (US) (For US Only)
Inventors: MOON, Malcolm, Wilson; (US).
MOROZOWICH, Walter; (US).
GAO, Ping; (US).
TANG, Peng, Cho; (US)
Agent: BURROUS, Beth, A.; Foley & Lardner 3000 K Street, N.W. Suite 500 Washington, DC 20007-5109 (US)
Priority Data:
60/207,000 24.05.2000 US
60/225,045 11.08.2000 US
Title (EN) MANNICH BASE PRODRUGS OF 3-(PYRROL-2-YLMETHYLIDENE)-2-INDOLINONE DERIVATIVES AND THEIR USE A MODULATORS OF PROTEIN KINASES
(FR) PROMEDICAMENTS A BASE DE MANNICH DE DERIVES DE 3-(PYRROL-2-YLMETHYLIDENE)-2-INDOLINONE
Abstract: front page image
(EN)The present invention is directed to Mannich base prodrugs of certain 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives of formula (I): that modulate the activity of protein kinases ('PKs'). Pharmaceutical compositions comprising these compounds, methods of treating diseases related to abnormal PK activity utilizing pharmaceutical compositions comprising these compounds and methods of preparing them are also disclosed.
(FR)L'invention concerne des promédicaments à base de Mannich de certains dérivés de 3-(pyrrol-2-ylméthylidène)-2-indolinone qui modulent l'activité de protéines kinases ('PK'). L'invention concerne également des compositions pharmaceutiques comprenant ces composés, des méthodes de traitement de maladies associées à une activité PK anormale au moyen des compositions pharmaceutiques comprenant ces composés ainsi que des méthodes de préparation de ces compositions pharmaceutiques.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)