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1. (WO2001090046) TRITERPENOID DERIVATIVES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2001/090046    International Application No.:    PCT/GB2001/002309
Publication Date: 29.11.2001 International Filing Date: 23.05.2001
Chapter 2 Demand Filed:    18.12.2001    
IPC:
A61K 31/215 (2006.01), A61K 31/56 (2006.01), C07J 63/00 (2006.01)
Applicants: UNIVERZITA PALACKEHO V OLOMOUCI [CZ/CZ]; Krizkovskeho 7, 772 00 Olomouc (CZ) (AE, AG, AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BY, BZ, CA, CF, CG, CH, CI, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GR, GW, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MC, MD, MG, MK, ML, MN, MR, MW, MX, MZ, NE, NL, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, SN, SZ, TD, TG, TJ, TM, TR, TZ, UA, UG, UZ, VN, YU, ZA, ZW only).
UNIVERZITA KARLOVA V PRAZE [CZ/CZ]; Ovocny trh 3/5, 110 00 Praha 1 (CZ) (AE, AG, AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BY, BZ, CA, CF, CG, CH, CI, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GR, GW, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MC, MD, MG, MK, ML, MN, MR, MW, MX, MZ, NE, NL, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, SN, SZ, TD, TG, TJ, TM, TR, TZ, UA, UG, UZ, VN, YU, ZA, ZW only).
CYCLACEL LIMITED [GB/GB]; 12 St. James's Square, London SW1Y 4RB (GB) (TT only).
HAJDUCH, Marian [CZ/CZ]; (CZ) (For US Only).
SAREK, Jan [CZ/CZ]; (CZ) (For US Only)
Inventors: HAJDUCH, Marian; (CZ).
SAREK, Jan; (CZ)
Agent: NACHSHEN, Neil, Jacob; D. Young & Co., 21 New Fetter Lane, London EC4A 1DA (GB)
Priority Data:
0012528.6 23.05.2000 GB
0012823.1 25.05.2000 GB
Title (EN) TRITERPENOID DERIVATIVES
(FR) DERIVES TRITERPENOIDES
Abstract: front page image
(EN)The present invention relates to the use of a compound of formula (I), or a pharmaceutically acceptable salt, crystal form, complex, hydrate, or hydrolysable ester thereof, in the preparation of a medicament for treating a patient suffering from leukaemia, cancer or other proliferative disorder. A further embodiment relates to the use a compound of formula (I) in an assay for detecting the phosphorylation state of cellular substrates. The present invention also relates to novel compounds of formula (I), and the chemical synthesis thereof.
(FR)La présente invention concerne l'utilisation d'un composé de la formule (I), ou d'un sel pharmaceutiquement acceptable, d'une forme, d'un complexe, d'un hydrate ou d'un ester hydrolysable dudit composé, dans la préparation d'un médicament destiné à traiter un patient atteint de leucémie, de cancer ou d'une autre maladie à évolution chronique. Dans une autre forme de réalisation, l'invention concerne l'utilisation d'un composé de la formule (I) dans un dosage servant à détecter l'état de phosphorylation de substrats cellulaires. L'invention concerne en outre de nouveaux composés de la formule (I) et la synthèse chimique desdits composés.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)