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1. WO2001089788 - PATTERNING OF SURFACES UTILIZING MICROFLUIDIC STAMPS INCLUDING THREE-DIMENSIONALLY ARRAYED CHANNEL NETWORKS

Publication Number WO/2001/089788
Publication Date 29.11.2001
International Application No. PCT/US2001/017246
International Filing Date 25.05.2001
Chapter 2 Demand Filed 05.12.2001
IPC
B PERFORMING OPERATIONS; TRANSPORTING
01
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
F
MIXING, e.g. DISSOLVING, EMULSIFYING, DISPERSING
13
Other mixers; Mixing plant, including combinations of dissimilar mixers
B PERFORMING OPERATIONS; TRANSPORTING
01
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
L
CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
3
Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
B PERFORMING OPERATIONS; TRANSPORTING
01
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
L
CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
3
Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
02
Burettes; Pipettes
B PERFORMING OPERATIONS; TRANSPORTING
29
WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
C
SHAPING OR JOINING OF PLASTICS; SHAPING OF SUBSTANCES IN A PLASTIC STATE, IN GENERAL; AFTER- TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
31
Handling, e.g. feeding of the material to be shaped
04
Feeding, e.g. into a mould cavity
B PERFORMING OPERATIONS; TRANSPORTING
29
WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
C
SHAPING OR JOINING OF PLASTICS; SHAPING OF SUBSTANCES IN A PLASTIC STATE, IN GENERAL; AFTER- TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
33
Moulds or cores; Details thereof or accessories therefor
42
characterised by the shape of the moulding surface, e.g. ribs, grooves
B PERFORMING OPERATIONS; TRANSPORTING
29
WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
C
SHAPING OR JOINING OF PLASTICS; SHAPING OF SUBSTANCES IN A PLASTIC STATE, IN GENERAL; AFTER- TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
39
Shaping by casting, i.e. introducing the moulding material into a mould or between confining surfaces without significant moulding pressure; Apparatus therefor
02
for making articles of definite length, i.e. discrete articles
10
incorporating preformed parts or layers, e.g. casting around inserts or for coating articles
B PERFORMING OPERATIONS; TRANSPORTING
81
MICRO-STRUCTURAL TECHNOLOGY
B
MICRO-STRUCTURAL DEVICES OR SYSTEMS, e.g. MICRO-MECHANICAL DEVICES
1
Devices without movable or flexible elements, e.g. micro-capillary devices
B PERFORMING OPERATIONS; TRANSPORTING
81
MICRO-STRUCTURAL TECHNOLOGY
C
PROCESSES OR APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OR TREATMENT OF MICRO-STRUCTURAL DEVICES OR SYSTEMS
1
Manufacture or treatment of devices or systems in or on a substrate
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
B01F 13/00 (2006.01)
B01L 3/00 (2006.01)
B01L 3/02 (2006.01)
B29C 31/04 (2006.01)
B29C 33/42 (2006.01)
B29C 39/10 (2006.01)
CPC
B01F 13/0059
B01J 2219/00382
B01J 2219/00527
B01J 2219/00585
B01J 2219/00596
B01J 2219/00605
Applicants
  • PRESIDENT AND FELLOWS OF HARVARD COLLEGE [US/US]; Holyoke Center Suite 727 1350 Massachusetts Avenue Cambridge, MA 02138, US (AllExceptUS)
  • CHILDREN'S MEDICAL CENTER CORPORATION [US/US]; 300 Longwood Avenue Boston, MA 02115, US (AllExceptUS)
  • CHIU, Daniel, T. [CA/US]; US (UsOnly)
  • JEON, Noo-Li [KR/US]; US (UsOnly)
  • HUANG, Sui [CH/US]; US (UsOnly)
  • KANE, Ravi [US/US]; US (UsOnly)
  • CHOI, Insung, S. [KR/US]; US (UsOnly)
  • INGBER, Donald, E. [US/US]; US (UsOnly)
  • WHITESIDES, George, M. [US/US]; US (UsOnly)
  • ANDERSON, Janelle, R. [CA/US]; US (UsOnly)
Inventors
  • CHIU, Daniel, T.; US
  • JEON, Noo-Li; US
  • HUANG, Sui; US
  • KANE, Ravi; US
  • CHOI, Insung, S.; US
  • INGBER, Donald, E.; US
  • WHITESIDES, George, M.; US
  • ANDERSON, Janelle, R.; US
Agents
  • OYER, Timothy, J.; Wolf, Greenfield & Sacks, P.C. 600 Atlantic Avenue Boston, MA 02210, US
Priority Data
09/578,56225.05.2000US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PATTERNING OF SURFACES UTILIZING MICROFLUIDIC STAMPS INCLUDING THREE-DIMENSIONALLY ARRAYED CHANNEL NETWORKS
(FR) FORMATION DE MOTIFS SUR DES SURFACES, AU MOYEN DE TAMPONS MICROFLUIDIQUES COMPRENANT DES RESEAUX DE CANAUX DISPOSES EN TROIS DIMENSIONS
Abstract
(EN)
The present invention describes improved microfluidic systems and procedures for fabricating improved microfluidic systems, which contain one or more levels of microfluidic channels. The methods for fabrication the systems disclosed can provide a convenient route to topologically complex and improved microfluidic systems. The microfluidic systems can include three-dimensionally arrayed networks of fluid flow paths therein including channels that cross over or under other channels of the network without physical intersection at the points of cross over. The microfluidic networks can be fabricated via replica molding processes utilizing mold masters including surfaces having topological features formed by photolithography. The present invention also involves microfluidic systems and methods for fabricating complex patterns of materials, such as biological materials and cells, on surfaces utilizing the microfluidic systems. Specifically, the invention provides microfluidic surface patterning systems and methods for fabricating complex, discontinuous patterns on surfaces that can incorporate or deposit multiple materials onto the surfaces. The present invention also provides improved microfluidic stamps or applicators for microcontact surface patterning, which are able to pattern onto a surface arbitrary two-dimensional patterns, and which are able to pattern multiple substances onto a surface without the need for multiple steps of registration or stamping during patterning and without the need to selectively 'ink' different regions of the stamp with different materials.
(FR)
L'invention concerne des système microfluidiques améliorés et des procédures de fabrication de systèmes microfluidiques, contenant au moins un niveau de canaux microfluidiques. Les procédés de fabrication des systèmes de l'invention permettent la création d'un réseau approprié de systèmes microfluidiques améliorés et complexes au plan topologique. Lesdits systèmes microfluidiques peuvent comporter des réseaux disposés en trois dimensions, de voies d'écoulement de fluide comportant des canaux qui passent au-dessus ou au-dessous d'autres canaux du réseau sans intersection physique au niveau des points de croisement. Les réseaux microfluidiques peuvent être fabriqués par des procédés de moulage de répliques, dans lesquels on utilise des moules originaux possédant des surfaces à caractéristiques topologiques formées par lithographie. L'invention porte également sur des systèmes microfluidiques et sur des procédés de fabrication de motifs complexes de matériaux, tels que des matériaux biologiques et des cellules, sur des surfaces dans lesquelles les systèmes microfluidiques sont utilisés. L'invention se rapporte notamment à des systèmes de formation de motifs sur des surfaces microfluidiques et à des procédés de fabrication de motifs discontinus complexe sur des surfaces, permettant l'insertion ou le dépôt de matériaux multiples sur lesdites surfaces. L'invention concerne encore des tampons ou des applicateurs microfluidiques pour la formation de motifs sur des surfaces par microcontact, permettant la formation sur une surface de motifs bidimensionnels arbitraires, et permettant la formation de motifs à l'aide de plusieurs substances sur une surface, sans que des étapes multiples d'alignement ou d'estampage pendant la formation de motif et qu'un encrage sélectif de différentes zones du tampon avec différents matériaux soient nécessaires.
Also published as
Latest bibliographic data on file with the International Bureau