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1. (WO2001089516) PHARMACEUTICAL COMBINATION OF BICALUTAMIDE AND ANASTROZOLE FOR PROVIDING AN ANTI-ANDROGENIC EFFECT AND AROMATASE INHIBITION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2001/089516    International Application No.:    PCT/SE2001/001163
Publication Date: 29.11.2001 International Filing Date: 22.05.2001
Chapter 2 Demand Filed:    20.11.2001    
IPC:
A61K 31/277 (2006.01), A61K 31/4196 (2006.01)
Applicants: ASTRAZENECA AB [SE/SE]; S-151 85 Södertälje (SE) (For All Designated States Except US).
COCKSHOTT, Ian [GB/GB]; (GB) (For US Only).
FURR, Barrington [GB/GB]; (GB) (For US Only)
Inventors: COCKSHOTT, Ian; (GB).
FURR, Barrington; (GB)
Agent: ASTRAZENECA AB; Global Intellectual Property S-151 85 Södertälje (SE)
Priority Data:
0012293.7 23.05.2000 GB
Title (EN) PHARMACEUTICAL COMBINATION OF BICALUTAMIDE AND ANASTROZOLE FOR PROVIDING AN ANTI-ANDROGENIC EFFECT AND AROMATASE INHIBITION
(FR) COMBINAISON PHARMACEUTIQUE DE BICALUTAMIDE ET D'ANASTROZOLE PERMETTANT D'OBTENIR UN EFFET ANTI-ANDROGENE ET L'INHIBITION DE L'AROMATASE
Abstract: front page image
(EN)The present invention relates to a pharmaceutical product, daily dose or dose regimen comprising 4'-cyano-$g(a)',$g(a)',$g(a)'-trifluoro-3-(4-fluorophenylsulphonyl)-2-hydroxy-2-methylpropriono-m-toluidide (compound I) and anastrozole. The invention also relates to a method of providing an anti-anrogenic effect and aromatase inhibition in a patient, wherein the aromatase inhibition is provided substantially without causing an additional increase in the levels of circulating androgens.
(FR)La présente invention concerne un produit pharmaceutique, une dose quotidienne ou un schéma posologique, comprenant du 4'-cyano-$g(a)',$g(a)',$g(a)'-trifluoro-3-(4-fluorophénylsulphonyl)-2-hydroxy-2-méthylpropriono-<i>m</i>-toluidide (composé I) et de l'anastrozole. L'invention concerne également une méthode permettant d'obtenir sensiblement un effet anti-androgène et l'inhibition de l'aromatase sans causer d'augmentation supplémentaire des niveaux d'androgènes circulant.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)