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1. (WO2001089468) USE OF ARYL OXIMES FOR THE PROPHYLAXIS AND/OR TREATMENT OF ERYTHEMA FORMATION AND/OR INFLAMMATORY REACTIONS OF THE SKIN
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2001/089468    International Application No.:    PCT/EP2001/005222
Publication Date: 29.11.2001 International Filing Date: 08.05.2001
Chapter 2 Demand Filed:    11.12.2001    
IPC:
A61K 8/40 (2006.01), A61Q 17/04 (2006.01)
Applicants: MERCK PATENT GMBH [DE/DE]; Frankfurter Strasse 250 64293 Darmstadt (DE) (For All Designated States Except US).
BÜNGER, Joachim [DE/DE]; (DE) (For US Only).
DRILLER, Hansjürgen [DE/DE]; (DE) (For US Only).
SCHWARZ, Michael [DE/DE]; (DE) (For US Only).
WOHLRAB, Wolfgang [DE/DE]; (DE) (For US Only)
Inventors: BÜNGER, Joachim; (DE).
DRILLER, Hansjürgen; (DE).
SCHWARZ, Michael; (DE).
WOHLRAB, Wolfgang; (DE)
Agent: GRÜNECKER, KINKELDEY, STOCKMAIR & SCHWANHAÜSSER; Maximilianstrasse 58 D-80538 München (DE)
Priority Data:
100 25 557.4 24.05.2000 DE
100 25 555.8 24.05.2000 DE
Title (DE) VERWENDUNG VON ARYLOXIMEN ZUR PROPHYLAXE UND/ODER BEHANDLUNG VON ERYTHEMBILDUNG UND/ODER ENTZÜNDUNGSREAKTIONEN DER HAUT
(EN) USE OF ARYL OXIMES FOR THE PROPHYLAXIS AND/OR TREATMENT OF ERYTHEMA FORMATION AND/OR INFLAMMATORY REACTIONS OF THE SKIN
(FR) UTILISATION D'ARYLOXIMES POUR ASSURER LA PROPHYLAXIE ET/OU LE TRAITEMENT DE LA FORMATION D'ERYTHEME ET/OU DE REACTIONS INFLAMMATOIRES DE LA PEAU
Abstract: front page image
(DE)Die vorliegende Erfindung betrifft die Verwendung von mindestens einem Aryloxim der Formel (I), worin bedeuten: Y, Z unabhängig voneinander H, C¿1-18?-Alkyl, C¿2-18?-Alkenyl, C¿2-18?-Carboxyalkyl, C¿3-18?-Carboxyalkenyl oder C¿2-18?-Alkanoyl; R C¿1-18?-Alkyl, C¿2-18?-Alkenyl, C¿3-8?-Cycloalkyl, Aryl, Aralkyl, Heteroaryl, Heteroaralkyl oder kondensierte Systeme; R¿1?, R¿2?, R¿3?, R¿4? unabhängig voneinander H, C¿1-12?-Alkyl, C¿2-12-Alkenyl, C¿1-12?-Alkoxy, C¿3-8?-Cycloalkoxy, Aryl, Aryloxy, Aralkyl, Heteroaryl, Heteroaralkyl, Carboxy, Hydroxy, Chlor, Dialkylamin oder Sulfonyl, zur Prophylaxe und/oder Behandlung von Erythembildung und/oder Entzündungsreaktionen der Haut.
(EN)The invention relates to the use of at least one aryl oxime of formula (I), wherein Y and Z, independent of one another, represent H, C¿1-18? alkyl, C¿2-18? alkenyl, C¿2-18? carboxyalkyl, C¿3-18? carboxyalkenyl or C¿2-18? alkanoyl; R represents C¿1-18? alkyl, C¿2-18? alkenyl, C¿3-8? cycloalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl or condensed systems; R?1¿, R?2¿, R?3¿ and R?4¿, independent of one another, represent H, C¿1-12? alkyl, C¿2-12? alkenyl, C¿1-12? alkoxy, C¿3-8? cycloalkoxy, aryl, aryloxy, aralkyl, heteroaryl, heteroaralkyl, carboxy, hydroxy, chlorine, dialkylamine or sulfonyl. The inventive aryl oxime is used for the prophylaxis and/or treatment of erythema formation and/or inflammatory reactions of the skin.
(FR)L'invention concerne l'utilisation pour assurer la prophylaxie et/ou le traitement de la formation d'érythème et/ou de réactions inflammatoires de la peau, d'au moins un aryloxime de formule (I) dans laquelle Y,Z désignent indépendamment l'un de l'autre H, alkyle C¿1-18?, alkényle C¿2-18?, carboxyalkyle C¿3-18?, carboxyalkényle C¿3-18? ou alkanoyle C¿2-18 ?; R désigne alkyle C¿1-18?, alkényle C¿2-18?, cycloalkyle C¿3?-¿8?, aryle, aralkyle, hétéroaryle, hétéroaralkyle ou des systèmes condensés ; R¿1?,R¿2?,R¿3?,R¿4? désignent indépendamment les uns des autres, H, alkyle C¿1-12?, alkényle C¿2-12?, alcoxy C¿1-12?, cycloalcoxy C¿3-8?, aryle, aryloxy, hétéroaryle, hétéroaralkyle, carboxy, hydroxy, chlore, dialkylamine ou sulfonyle.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: German (DE)
Filing Language: German (DE)