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1. (WO2001089456) HYBRID LT-A/CT-B HOLOTOXIN FOR USE AS AN ADJUVANT
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2001/089456    International Application No.:    PCT/US2001/016542
Publication Date: 29.11.2001 International Filing Date: 21.05.2001
Chapter 2 Demand Filed:    11.12.2001    
IPC:
A61K 39/39 (2006.01)
Applicants: THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND [US/US]; 1430 Tulane Avenue, New Orleans, LA 70112 (US) (AE, AG, AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BY, BZ, CA, CF, CG, CH, CI, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DZ, EE, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GR, GW, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MC, MD, MG, MK, ML, MN, MR, MW, MX, MZ, NE, NL, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, SN, SZ, TD, TG, TJ, TM, TR, TT, TZ, UA, UG, UZ, VN, YU, ZA, ZW only).
CLEMENTS, John, D. [US/US]; (US) (For US Only)
Inventors: CLEMENTS, John, D.; (US)
Agent: BALDWIN, Geraldine, F.; Pennie & Edmonds LLP, 1155 Avenue of the Americas, New York, NY 10036 (US)
Priority Data:
60/205,969 19.05.2000 US
Title (EN) HYBRID LT-A/CT-B HOLOTOXIN FOR USE AS AN ADJUVANT
(FR) HOLOTOXINE HYBRIDE LT-A/CT-B UTILISE EN TANT QU'ADJUVANT
Abstract: front page image
(EN)The present invention provides a novel composition which is a hybrid heat labile enterotoxin comprising the A-subunit of the heat labile toxin of Escherichia coli (LT-A) and the B-subunit of the cholera enterotoxin Vibrio cholerae (CT-B). The hybrid toxin is designated LT-A/CT-B. The LT-A subunit, the CT-B subunit, or both subunits of the hybrid toxin may be mutant subunits e.g., differing from wild-type subunits by amino acid substitutions, deletions or additions. Also provided are methods of using the novel LT-A/CT-B comprising compositions of the invention as adjuvants for vaccines, methods of making the LT-A/CT-B hybrid holotoxin, and kits.
(FR)L'invention concerne une nouvelle composition consistant en une entérotoxine hybride instable à la chaleur et comprenant la sous-unité A de la toxine instable à la chaleur d'<i>escherichia coli</i> (LT-A) et la sous-unité B de l'entérotoxine du choléral de <i>vibrio cholerae</i> (CT-B). Cette toxine hybride est désignée LT-A/CT-B. La sous-unité LT-A, la sous-unité CT-B ou les deux sous-unités de cette toxine hybride peuvent être des sous-unités mutantes, par exemple, différentes des sous-unités de type sauvage par des substitutions, des effacements ou des additions aminoacides. Elle concerne également des procédés d'utilisation de ces nouvelles compositions contenant LT-A/CT-B en tant qu'adjuvants de vaccins, des procédés de préparation de cette holotoxine hybride LT-A/CT-B, ainsi que des trousses.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)