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Pub. No.:    WO/2001/088104    International Application No.:    PCT/US2001/015861
Publication Date: 22.11.2001 International Filing Date: 16.05.2001
Chapter 2 Demand Filed:    17.12.2001    
A61K 35/30 (2006.01), A61K 45/00 (2006.01), A61P 25/00 (2006.01), C12N 15/09 (2006.01), A61P 25/08 (2006.01), A61P 25/14 (2006.01), A61P 25/16 (2006.01), A61P 25/28 (2006.01), A61P 9/08 (2006.01), A61P 9/10 (2006.01), C12N 5/0797 (2010.01), C12N 5/10 (2006.01), C12Q 1/02 (2006.01), C12Q 1/68 (2006.01), A61K 35/12 (2006.01)
Applicants: GERON CORPORATION [US/US]; 230 Constitution Drive Menlo Park, CA 94025 (US) (For All Designated States Except US).
CARPENTER, Melissa, K. [US/US]; (US) (For US Only)
Inventors: CARPENTER, Melissa, K.; (US)
Agent: SCHIFF, J., Michael; Geron Corporation 230 Constitution Drive Menlo Park, CA 94025 (US).
BASSIL, Nicholas, Charles; Kilburn & Strode 20 Red Lion Street London WC1R 4PJ (GB)
Priority Data:
60/205,600 17.05.2000 US
60/257,608 22.12.2000 US
Abstract: front page image
(EN)The invention provides populations of neural progenitor cells, differentiated neurons, glial cells, and astrocytes. The populations are obtained by culturing stem cell populations (such as embryonic stem cells) in a cocktail of growth conditions that initiates differentiation, and establishes the neural progenitor population. The progenitors can be further differentiated in culture into a variety of different neural phenotypes, including dopaminergic neurons. The differentiated cell populations or the neural progenitors can be generated in large quantities for use in drug screening and the treatment of neurological disorders.
(FR)La présente invention concerne des populations de progéniteurs neuronaux, de neurones différenciés, de cellules gliales et d'astrocytes. Pour obtenir lesdites populations, on cultive des populations de cellules souches (telles que des cellules souches embryonnaires) dans un cocktail de conditions de croissance permettant le déclenchement de la différenciation et l'établissement de la population de progéniteurs neuronaux. Dans la culture, lesdits progéniteurs peuvent être, en outre, différenciés en divers phénotypes neuronaux différents, notamment en neurones dopaminergiques. Les populations de cellules différenciées ou les progéniteurs neuronaux selon l'invention peuvent être produits en grandes quantités, en vue d leur utilisation dans le criblage de médicaments et le traitement des troubles neurologiques.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)