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1. (WO2001087890) THIENODIBENZOAZULENE COMPOUNDS AS TUMOR NECROSIS FACTOR INHIBITORS

Pub. No.:    WO/2001/087890    International Application No.:    PCT/HR2001/000027
Publication Date: Nov 22, 2001 International Filing Date: May 16, 2001
IPC: C07D 495/04
Applicants: PLIVA, FARMACEUTSKA INDUSTRIJA, DIONIKO DRUSTVO
MERćEP, Mladen
MESIć, Milan
PEšIć, Dijana
žUPANOVIć, željko
HRVAčIć, Boška
Inventors: MERćEP, Mladen
MESIć, Milan
PEšIć, Dijana
žUPANOVIć, željko
HRVAčIć, Boška
Title: THIENODIBENZOAZULENE COMPOUNDS AS TUMOR NECROSIS FACTOR INHIBITORS
Abstract:
The present invention relates to the dibenzoazulene compounds represented by formula I as well as to their pharmaceutical preparations for the inhibition of tumor necrosis factor alpha (TNF-α) and interleukine 1 (IL-1) in mammals at all diseases and conditions where these mediators are excessively secreted. The compounds of the present invention also demonstrate an analgetic action and can be used to relieve pain.