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1. (WO2001087880) 1-(BENZOTHIAZOL-2-YL)PYRAZOLE DERIVATIVES AND COX-2 INHIBITORS CONTAINING THE SAME
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2001/087880    International Application No.:    PCT/JP2001/003940
Publication Date: 22.11.2001 International Filing Date: 11.05.2001
Chapter 2 Demand Filed:    11.05.2001    
IPC:
A61K 31/428 (2006.01), C07D 417/04 (2006.01)
Applicants: GRELAN PHARMACEUTICAL CO., LTD. [JP/JP]; 4-3, Sakaecho 3-Chome Hamura-shi Tokyo 205-8501 (JP) (For All Designated States Except US).
AOTSUKA, Tomoji [JP/JP]; (JP) (For US Only).
WAGATSUMA, Nagatoshi [JP/JP]; (JP) (For US Only).
ISHITANI, Kouki [JP/JP]; (JP) (For US Only).
KATO, Hideaki [JP/JP]; (JP) (For US Only)
Inventors: AOTSUKA, Tomoji; (JP).
WAGATSUMA, Nagatoshi; (JP).
ISHITANI, Kouki; (JP).
KATO, Hideaki; (JP)
Agent: MIZUNO, Akinobu; Lions Mansion Shibuya Dogenzaka 303 22-12, Maruyama-cho Shibuya-ku Tokyo 150-0044 (JP)
Priority Data:
2000-141316 15.05.2000 JP
Title (EN) 1-(BENZOTHIAZOL-2-YL)PYRAZOLE DERIVATIVES AND COX-2 INHIBITORS CONTAINING THE SAME
(FR) DERIVES DE 1-(BENZATHIAZOL-2-YL)PYRAZOLE ET INHIBITEURS DE COX-2 EN CONTENANT
Abstract: front page image
(EN)Anti-inflammatory drugs are provided, which are excellent in pharmacological effects and exhibit a selective COX-2-inhibitory activity expected to relieve the side effects including gastric mucosa disorders. Specifically, compounds of the general formula (1) or medicinally acceptable salts thereof; and COX-2 inhibitors containing the compounds or the salts, wherein R?1¿ is hydrogen, halogeno, lower alkyl, or lower alkoxy; R?2¿ is halogenated lower alkyl or lower alkyl; R?3¿ is lower alkyl; and n is an integer of 0 to 2.
(FR)La présente invention concerne des médicaments anti-inflammatoires, ayant d'excellents effets pharmacologiques et présentant une activité inhibitrice sélective vis-à-vis du COX-2 permettant de soulager les effets secondaires y compris des troubles de la muqueuse gastrique. Plus particulièrement, l'invention concerne des composés de la formule générale (1) dans laquelle: R?1¿ est hydrogène, halogène, alkyle inférieur ou alcoxy inférieur; R?2¿ est alkyle inférieur halogéné ou alkyle inférieur; R?3¿ est alkyle inférieur; et n est un entier de 0 à 2; ou de leurs sels médicalement acceptables; et des inhibiteurs de COX-2 contenant ces composés ou leurs sels.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)