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1. (WO2001087272) ENCAPSULATING A TOXIC CORE WITHIN A NON-TOXIC REGION IN AN ORAL DOSAGE FORM
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2001/087272    International Application No.:    PCT/US2001/040763
Publication Date: 22.11.2001 International Filing Date: 18.05.2001
Chapter 2 Demand Filed:    12.12.2001    
IPC:
A61K 9/20 (2006.01), A61K 9/28 (2006.01)
Applicants: THERICS, INC. [US/US]; 115 Campus Drive Princeton, NJ 08540 (US) (For All Designated States Except US).
MASSACHUSETTS INSTITUTE OF TECHNOLOGY [US/US]; 77 Massachusetts Avenue Cambridge, MA 02139 (US) (For All Designated States Except US).
PAYUMO, Francis, C. [US/US]; (US) (For US Only).
WANG, Chen-Chao [--/US]; (US) (For US Only).
SHERWOOD, Jill, K. [US/US]; (US) (For US Only).
CIMA, Michael, J. [US/US]; (US) (For US Only).
GAYLO, Christopher, M. [US/US]; (US) (For US Only).
MONKHOUSE, Donald, C. [US/US]; (US) (For US Only).
YOO, Jaedeok [US/US]; (US) (For US Only)
Inventors: PAYUMO, Francis, C.; (US).
WANG, Chen-Chao; (US).
SHERWOOD, Jill, K.; (US).
CIMA, Michael, J.; (US).
GAYLO, Christopher, M.; (US).
MONKHOUSE, Donald, C.; (US).
YOO, Jaedeok; (US)
Agent: BETCHER, Susan, D.; Seed Intellectual Property Law Group PLLC Suite 6300 701 Fifth Avenue Seattle, WA 98104-7092 (US).
ZIMMER, F.J.; Maximiliansrasse 58 80538 München (DE)
Priority Data:
60/205,896 18.05.2000 US
Title (EN) ENCAPSULATING A TOXIC CORE WITHIN A NON-TOXIC REGION IN AN ORAL DOSAGE FORM
(FR) PROCEDE ET FORME D'UN DISPOSITIF D'ADMINISTRATION DE MEDICAMENT, PAR EXEMPLE ENROBER UN NOYAU TOXIQUE A L'INTERIEUR D'UNE ZONE NON TOXIQUE EN FORME POSOLOGIQUE ORALE
Abstract: front page image
(EN)A drug delivery device such as an oral dosage form (ODF) with a toxic or potent core encapsulated by a non-toxic region. The non-toxic region may be a region including multiple layers, coatings, shells, and combinations thereof, which provides protection to and isolation from the toxic or potent core. The drug in the toxic or potent core is incorporated into the dosage form via, for example, three-dimensional printing, as a solution, solubilization or suspension of solid particles in liquid, rather than by the more conventional handling and compressing of dry powder. This minimizes the likelihood of creating airborne particles of the toxic drug during manufacturing, hence controlling and minimizing the exposure of manufacturing personnel to the hazardous substance. Wet dispensing of the toxic or potent drug further provides greater bioavailability of the drug to the patient.
(FR)L'invention concerne un dispositif d'administration de médicament, par exemple une forme posologique orale avec un noyau toxique ou actif enrobé d'une zone non toxique. Cette zone peut comporter plusieurs couches, revêtements, enveloppes ainsi que des combinaisons de ceux-ci, ce qui permet de protéger et d'isoler le noyau actif ou toxique. Le médicament contenu dans ledit noyau est incorporé dans la forme posologique par le biais, par exemple, d'impression tridimensionnelle, comme solution, solubilisation ou suspension de particules solides dans un liquide, plutôt que par le traitement et la compression plus classiques de poudre sèche. On minimise la probabilité de créer des particules aériennes du médicament toxique lors de la fabrication. Ainsi, on contrôle et on minimise l'exposition du personnel de fabrication à la matière dangereuse. La distribution humide du médicament toxique ou actif offre en outre au patient une plus grande biodisponibilité du médicament.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)