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Machine translation
1. (WO2001085952) MODIFIED INOSINE 5'-MONOPHOSPHATE DEHYDROGENASE POLYPEPTIDES AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2001/085952    International Application No.:    PCT/US2001/015457
Publication Date: 15.11.2001 International Filing Date: 10.05.2001
Chapter 2 Demand Filed:    21.11.2001    
IPC:
C12N 9/04 (2006.01)
Applicants: BRISTOL-MYERS SQUIBB COMPANY [US/US]; Lawrenceville-Princeton Road, P.O. Box 4000, Princeton, NJ 08543-4000 (US) (For All Designated States Except US).
KRYSTEK, Stanley, R. [US/US]; (US) (For US Only).
SHERIFF, Steven [US/US]; (US) (For US Only).
WITMER, Mark, R. [US/US]; (US) (For US Only).
HOLLENBAUGH, Diane, L. [US/US]; (US) (For US Only).
YAN, Ning [US/US]; (US) (For US Only).
MOURAVIEFF, Julie, E. [US/US]; (US) (For US Only).
EINSPAHR, Howard, M. [US/US]; (US) (For US Only).
KISH, Kevin [US/US]; (US) (For US Only)
Inventors: KRYSTEK, Stanley, R.; (US).
SHERIFF, Steven; (US).
WITMER, Mark, R.; (US).
HOLLENBAUGH, Diane, L.; (US).
YAN, Ning; (US).
MOURAVIEFF, Julie, E.; (US).
EINSPAHR, Howard, M.; (US).
KISH, Kevin; (US)
Agent: SHER, Audrey; Bristol-Myers Squibb Company, Lawrenceville-Princeton Road, P.O. Box 4000, Princeton, NJ 08543-4000 (US)
Priority Data:
60/203,448 10.05.2000 US
Title (EN) MODIFIED INOSINE 5'-MONOPHOSPHATE DEHYDROGENASE POLYPEPTIDES AND USES THEREOF
(FR) POLYPEPTIDES A BASE DE 5'-MONOPHOSPHATE DESHYDROGENASE INOSINE MODIFIEE ET LEURS UTILISATIONS
Abstract: front page image
(EN)The present invention provides isolated modified inosine 5'-monophosphate dehydrogenase (IMPDH) polypeptides. These modified IMPDH polypeptides comprise a substitute oligo-peptide that replaces the subdomain region. The modified polypeptides of the invention bind to an inhibitor, such as MPA, and/or exhibit functional activity of wild-type IMPDH holo-enzyme.
(FR)La présente invention concerne des polypeptides IMPDH, en l'occurrence des 5'-monophosphate déshydrogénase inosine, modifiés, qui ont été isolés. Ces IMPDH modifiés comprennent un oligo-peptide de substitution qui remplace la région de sous-domaine. Les polypeptides modifiés de l'invention se lient à un inhibiteur tel que le MPA, et/ou font preuve d'une activité fonctionnelle de holo-enzyme d'IMPDH de type sauvage.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)