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1. (WO2001083750) DENDRITIC CELL CO-STIMULATOR MOLECULES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2001/083750    International Application No.:    PCT/US2001/013430
Publication Date: 08.11.2001 International Filing Date: 27.04.2001
Chapter 2 Demand Filed:    28.11.2001    
IPC:
A61K 38/00 (2006.01), C07K 14/705 (2006.01), C07K 16/28 (2006.01)
Applicants: THE JOHNS HOPKINS UNIVERSITY [US/US]; 720 Rutland Avenue Baltimore, MD 21205 (US) (For All Designated States Except US).
PARDOLL, Drew, M. [US/US]; (US) (For US Only).
TSUCHIYA, Haruo [JP/US]; (US) (For US Only).
GORSKI, Kevin, S. [US/US]; (US) (For US Only).
TSENG, Su-Yi [US/US]; (US) (For US Only)
Inventors: PARDOLL, Drew, M.; (US).
TSUCHIYA, Haruo; (US).
GORSKI, Kevin, S.; (US).
TSENG, Su-Yi; (US)
Agent: LIVNAT, Shmuel; Venable, Baetjer, Howard & Civiletti, LLP 1201 New York Avenue, NW Suite 1000 P.O. Box 34385 Washington, DC 20043-9998 (US)
Priority Data:
60/200,580 28.04.2000 US
60/240,169 13.10.2000 US
09/ 28.02.2001 US (IA Considered Withdrawn 28.01.2002)
Title (EN) DENDRITIC CELL CO-STIMULATOR MOLECULES
(FR) NOUVELLES MOLECULES CO-STIMULANTES DE CELLULE DENDRITIQUE
Abstract: front page image
(EN)A costimulatory protein molecule, B7-DC, which is a member of the B7 family, is described as is DNA coding therefor and expression vectors comprising this DNA. B7-DC protein, fragments, fusion polypeptides/proteins and other functional derivatives, and transformed cells expressing B7-DC are useful in vaccine compositions and methods. Compositions and methods are disclosed for inducing potent T cell mediated responses that can be harnessed for anti-tumor and anti-viral immunity.
(FR)La présente invention concerne une nouvelle molécule de protéine co-stomulante, B7-DC, qui est un membre de la famille B7, un ADN codant pour cette molécule, des vecteurs d'expression comprenant cette protéine B7-DC d'ADN, des fragments, des protéines/polypeptides de fusion et d'autres dérivés fonctionnels et enfin des cellules transformées exprimant B7-DC, qui conviennent pour des compositions et des techniques de vaccin. Cette invention concerne aussi des compositions et des techniques permettant d'induire des réponses efficaces induites par un lymphocyte T qui peuvent être maîtrisées en vue de renforcer l'immunité contre les tumeurs et les virus.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)