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1. (WO2001083478) HYDANTOIN-CONTAINING GLUCOKINASE ACTIVATORS

Pub. No.:    WO/2001/083478    International Application No.:    PCT/EP2001/004555
Publication Date: Nov 8, 2001 International Filing Date: Apr 23, 2001
IPC: C07D 401/12
C07D 417/12
C07D 417/14
Applicants: F. HOFFMANN-LA ROCHE AG
Inventors: GOODNOW, Robert, Alan, Jr.
LE, Kang
Title: HYDANTOIN-CONTAINING GLUCOKINASE ACTIVATORS
Abstract:
Hydantoin compounds of the formula: wherein R1 is a five-or-six-membered aromatic heterocyclic ring having one to three heteroatoms selected from nitrogen, oxygen, and sulfur, which ring is unsubstituted or substituted with halo, amino, hydroxylamino, nitro, cyano, sulfonamido, lower alkyl, perfluoro lower alkyl, lower alkyl thio, perfluoro-lower alkyl thio, lower alkyl sulfonyl, perfluoro-lower alkyl sulfonyl, lower alkyl sulfinyl, or-(R¿5?)n-C(O)-OR6; R2 is a cycloalkyl ring containing from 5 to 7 carbon atoms; which are active as glucokinase activators to increase insulin secretion which makes them useful for treating type II diabetes.