WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2001083476) CHROMENYLMETHYL PYRIMIDINEDIAMINES AS ANTIBACTERIAL AGENTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2001/083476    International Application No.:    PCT/EP2001/004541
Publication Date: 08.11.2001 International Filing Date: 20.04.2001
Chapter 2 Demand Filed:    12.11.2001    
IPC:
C07D 405/06 (2006.01), C07D 409/14 (2006.01), C07D 491/10 (2006.01), C07D 493/10 (2006.01), C07F 7/08 (2006.01)
Applicants: BASILEA PHARMACEUTICA AG [CH/CH]; c/o Rudolf Maag, Neuhofweg 11, 4102 Binningen (CH) (AE, AG, AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BY, BZ, CA, CF, CG, CH, CI, CM, CN, CO, CU, CY, CZ, DE, DK, DZ, EE, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GR, GW, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MC, MD, MG, MK, ML, MN, MR, MW, MX, MZ, NE, NL, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, SN, SZ, TD, TG, TJ, TM, TR, TT, TZ, UA, UG, UZ, VN, YU, ZA, ZW only).
MOHR, Peter [CH/CH]; (CH) (For US Only).
PFLIEGER, Philippe [FR/FR]; (FR) (For US Only)
Inventors: MOHR, Peter; (CH).
PFLIEGER, Philippe; (FR)
Agent: KJELLSAA-BERGER, Hanny; 124 Grenzacherstrasse, CH-4070 Basle (CH)
Priority Data:
00108945.7 27.04.2000 EP
Title (EN) CHROMENYLMETHYL PYRIMIDINEDIAMINES AS ANTIBACTERIAL AGENTS
(FR) CHROMENYLMETHYL PYRIMIDINEAMINES COMME AGENTS ANTIBACTERIENS
Abstract: front page image
(EN)This invention is concerned with substituted chromene derivatives of the general formula (I) in which R?1¿ represents alkyl or cycloalkylalkyl, R?2¿ and R?3¿ each independently represent alkyl or cycloalkyl or taken together with the adjacent carbon atom represent a saturated 3- to 6- membered carbocyclic or heterocyclic ring, the alkyl, cycloalkyl, carbocyclic or heterocyclic ring being unsubstituted or substituted, and R?4¿ represents hydrogen, halogen cyano, alkyl, alkylthio, alkenyl, alkynyl, hydroxyalkyl, hydroxyalkynyl, alkoxyalkyl, alkoxyalkynyl, trialkylsilyl, aryl or heteroaryl, and pharmaceutically acceptable acid addition salts of these compounds, their use as therapeutically active substances; medicaments based on these substances, optionally in combination with sulphonamides, and their production; the use of these substances as medicaments and for the production of antibacterially-active medicaments; as well as the manufacture of the compounds of formula (I) and their pharmaceutically acceptable acid addition salts and intermediates for their manufacture.
(FR)L'invention concerne des dérivés substitués de chromène représentés par la formule générale (I) dans laquelle R?1¿ représente alkyle ou cycloalkylalkyle, R?2¿ et R?3¿ représentent chacun indépendamment alkyle ou cycloalkyle ou conjointement avec l'atome de carbone adjacent représentent un noyau carbocyclique ou hétérocyclique saturé comprenant de 3 à 6 éléments, le noyau alkyle, cycloalkyle, carbocyclique ou hétérocyclique étant non substitué ou substitué et R?4¿ représente hydrogène, cyano, alkyle, alkylthio, alcényle, alkynyle, hydroxyalkyle, hydroxyalkynyle, alcoxyalkynyle, trialkylsilyle, aryle ou hétéroaryle. L'invention concerne également des sels d'addition acides pharmaceutiquement acceptables de ces composés, leur utilisation comme substances actives, des médicaments à base de ces substances, éventuellement combinés avec des sulphonamides, leur production, l'utilisation de ces substances comme médicaments et pour la production de médicaments à action antibactérienne, enfin la fabrication de composés représentés par la formule (I) et de leurs sels d'addition acides pharmaceutiquement acceptables ainsi que d'intermédiaires pour leur fabrication.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CU, CZ, DE, DK, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)