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1. WO2001083456 - CONDENSED HETEROARYL DERIVATIVES

Publication Number WO/2001/083456
Publication Date 08.11.2001
International Application No. PCT/JP2001/003650
International Filing Date 26.04.2001
Chapter 2 Demand Filed 23.10.2001
IPC
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
4353
ortho- or peri-condensed with heterocyclic ring systems
4355
the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
4353
ortho- or peri-condensed with heterocyclic ring systems
4365
the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
4353
ortho- or peri-condensed with heterocyclic ring systems
437
the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
4427
containing further heterocyclic ring systems
444
containing a six-membered ring with nitrogen as a ring hetero atom, e.g. amrinone
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519
ortho- or peri-condensed with heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
535
having six-membered rings with at least one nitrogen and at least one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
5375
1,4-Oxazines, e.g. morpholine
5377
not condensed and containing further heterocyclic rings, e.g. timolol
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
491
Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/-C07D459/290
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A61K 31/4355 (2006.01)
A61K 31/4365 (2006.01)
A61K 31/437 (2006.01)
A61K 31/444 (2006.01)
A61K 31/519 (2006.01)
A61K 31/5377 (2006.01)
CPC
A61K 31/4355
A61K 31/4365
A61K 31/437
A61K 31/444
A61K 31/519
A61K 31/5377
Applicants
  • YAMANOUCHI PHARMACEUTICAL CO., LTD. [JP/JP]; 3-11, Nihonbashi-Honcho 2-chome Chuo-ku, Tokyo 103-8411, JP (AllExceptUS)
  • LUDWIG INSTITUTE FOR CANCER RESEARCH [US/US]; 605, Third Avenue New York, NY 10158, US (AllExceptUS)
  • IMPERIAL CANCER RESEARCH TECHNOLOGY LTD. [GB/GB]; Sardinia House Sardinia Street, London WC2A 3NL, GB (AllExceptUS)
  • HAYAKAWA, Masahiko [JP/JP]; JP (UsOnly)
  • KAIZAWA, Hiroyuki [JP/JP]; JP (UsOnly)
  • MORITOMO, Hiroyuki [JP/JP]; JP (UsOnly)
  • KAWAGUCHI, Ken-ichi [JP/JP]; JP (UsOnly)
  • KOIZUMI, Tomonobu [JP/JP]; JP (UsOnly)
  • YAMANO, Mayumi [JP/JP]; JP (UsOnly)
  • MATSUDA, Koyo [JP/JP]; JP (UsOnly)
  • OKADA, Minoru [JP/JP]; JP (UsOnly)
  • OHTA, Mitsuaki [JP/JP]; JP (UsOnly)
Inventors
  • HAYAKAWA, Masahiko; JP
  • KAIZAWA, Hiroyuki; JP
  • MORITOMO, Hiroyuki; JP
  • KAWAGUCHI, Ken-ichi; JP
  • KOIZUMI, Tomonobu; JP
  • YAMANO, Mayumi; JP
  • MATSUDA, Koyo; JP
  • OKADA, Minoru; JP
  • OHTA, Mitsuaki; JP
Agents
  • NAGAI, Shozo ; c/o Yamanouchi Pharmaceutical Co., Ltd. Patent Department 17-1, Hasune 3-chome Itabashi-ku, Tokyo 174-8612, JP
Priority Data
2000-12847227.04.2000JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) CONDENSED HETEROARYL DERIVATIVES
(FR) DERIVES D'HETEROARYLE CONDENSES
Abstract
(EN)
Medicinal compositions which are useful as phosphatidylinositol 3-kinase (PI3K) inhibitors and anticancer agents; and novel bicyclic or tricyclic condensed heteroaryl derivatives or salts thereof having favorable effects of inhibiting PI3K and suppressing the proliferation of cancer cells.
(FR)
L'invention concerne des compositions médicinales s'utilisant comme inhibiteurs de phosphatidylinositol 3-kinase (PI3K) et comme agents anticancéreux. L'invention concerne également de nouveaux dérivés d'hétéroaryle condensés bicycliques ou tricycliques ou leurs sels produisant des effets bénéfiques sur l'inhibition de la PI3K et sur la prolifération de cellules cancéreuses.
Other related publications
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