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1. (WO2001082920) TREATMENT OF CONGESTIVE HEART FAILURE WITH A COMPOSITION COMPRISING A DIURETIC AGENT AND A VASOPRESSIN ANTAGONIST
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2001/082920    International Application No.:    PCT/US2001/009265
Publication Date: 08.11.2001 International Filing Date: 22.03.2001
Chapter 2 Demand Filed:    27.11.2001    
IPC:
A61K 31/635 (2006.01)
Applicants: WARNER-LAMBERT COMPANY [US/US]; 201 Tabor Road Morris Plains, NJ 07950 (US) (AE, AG, AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BY, BZ, CA, CF, CG, CH, CI, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DZ, EE, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GR, GW, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MC, MD, MG, MK, ML, MN, MR, MW, MX, MZ, NE, NL, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, SN, SZ, TD, TG, TJ, TM, TR, TT, TZ, UA, UG, UZ, VN, YU, ZA, ZW only).
BAKKER-ARKEMA, Rebecca, Guggemos [US/US]; (US) (For US Only).
PRESSLER, Milton, Lethan [US/US]; (US) (For US Only)
Inventors: BAKKER-ARKEMA, Rebecca, Guggemos; (US).
PRESSLER, Milton, Lethan; (US)
Agent: FEDERMAN, Evan, J.; Warner-Lambert Company 201 Tabor Road Morris Plains, NJ 07950 (US).
TESCH, Rudolph; Warner-Lambert Company Legal Division, Patent Department c/o Gödecke GmbH Mooswaldallee 1 79090 Freiburg (DE)
Priority Data:
60/201,431 03.05.2000 US
Title (EN) TREATMENT OF CONGESTIVE HEART FAILURE WITH A COMPOSITION COMPRISING A DIURETIC AGENT AND A VASOPRESSIN ANTAGONIST
(FR) TRAITEMENT DE L'INSUFFISANCE CARDIAQUE CONGESTIVE
Abstract: front page image
(EN)Combinations of diuretics and vasopressin antagonists are useful to slow and reverse the symptoms and process of congestive heart failure, to increase the excretion of water in the urine, and to decrease the excretion of sodium and potassium ions in urine. Preferred vasopressin antagonists have the formula (I) wherein R and R?5¿ are hydrogen or lower alkyl; R?1¿, R?2¿, and R?3¿ are hydrogen, halo, alkyl, alkoxy, and amino; and R?4¿ is hydrogen or phenyl, and a pharmaceutically acceptable salt thereof.
(FR)L'invention concerne des combinaisons de diurétiques et d'antagonistes de vasopressine servant à ralentir et à inverser les symptômes et le processus d'insuffisance cardiaque congestive, afin d'augmenter l'excrétion d'eau dans l'urine, et de réduire l'excrétion d'ions sodium et d'ions potassium dans l'urine. Les antagonistes de vasopressine préférés sont représentés par la formule dans laquelle R et R?5¿ sont hydrogène ou alkyle inférieur; R?1¿, R?2¿, et R?3¿ sont hydrogène, halo, alkyle, alkoxy, et amino; et R?4¿ est hydrogène ou phényle, et un sel acceptable d'un point de vue pharmaceutique.
Designated States: AE, AG, AL, AU, BA, BB, BG, BR, BZ, CA, CN, CO, CR, CU, CZ, DM, DZ, EE, GD, GE, HR, HU, ID, IL, IN, IS, JP, KP, KR, LC, LK, LR, LT, LV, MA, MG, MK, MN, MX, MZ, NO, NZ, PL, RO, SG, SI, SK, SL, TR, TT, UA, US, UZ, VN, YU, ZA.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)