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1. (WO2001081327) NOVEL STABLE CRYSTAL OF THIAZOLIDINEDIONE DERIVATIVE AND PROCESS FOR PRODUCING THE SAME
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2001/081327 International Application No.: PCT/JP2001/003450
Publication Date: 01.11.2001 International Filing Date: 23.04.2001
Chapter 2 Demand Filed: 20.11.2001
IPC:
C07D 277/34 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
277
Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
02
not condensed with other rings
20
having two or three double bonds between ring members or between ring members and non-ring members
32
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
34
Oxygen atoms
Applicants:
KYORIN PHARMACEUTICAL CO., LTD. [JP/JP]; 5, Kanda Surugadai 2-chome Chiyoda-ku Tokyo 101-0062, JP (AllExceptUS)
OHNOTA, Michiro [JP/JP]; JP (UsOnly)
ORITA, Kazuo [JP/JP]; JP (UsOnly)
Inventors:
OHNOTA, Michiro; JP
ORITA, Kazuo; JP
Agent:
MINOURA, Kiyoshi; Kudan Building, 7th floor 2-2, Kudankita 3-chome Chiyoda-ku Tokyo 102-0073, JP
Priority Data:
2000-12400625.04.2000JP
Title (EN) NOVEL STABLE CRYSTAL OF THIAZOLIDINEDIONE DERIVATIVE AND PROCESS FOR PRODUCING THE SAME
(FR) NOUVEAU CRISTAL STABLE DE DERIVE THIAZOLIDINEDIONE ET SON PROCEDE DE PRODUCTION
Abstract:
(EN) A homogeneous crystal having excellent stability which is suitable for the industrial-scale production of 5-[(2,4-dioxothiazolidin-5-yl)methyl]-2-methoxy-N-[[4-(trifluoromethyl)phenyl]methyl]benzamide (KRP-297). The novel crystal of KRP-297 is produced through recrystallization from an alcohol solvent. It is characterized by having diffraction angles (2$g(u)) at at least 9.7°, 15.0°, and 22.5° in X-ray powder diffractometry.
(FR) L'invention concerne un cristal homogène possédant une excellente stabilité, approprié pour la production du 5-[(2,4-dioxothiazolidin-5-yl)methyl]-2-methoxy-N-[[4-(trifluoromethyl)phenyl]methyl]benzamide (KRP-297) à l'échelle industrielle. Ce nouveau cristal de KPR-297 est produit par recristallisation à partir d'un solvant d'alcool. Il est caractérisé en ce qu'il possède des angles de diffraction (2$g(u)) d'au moins 9,5°, 15,0°, et 22,5° dans une diffractométrie de poudre aux rayons X.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)
Also published as:
BZ88.315.2002CZPV2002-3502HRP20020846AIS6586NO20025069NZ521936
SK15142002UZ20020763YUP-803/02MXPA/a/2002/010545KR1020030007548SG92316
VN7861ZA2002/08293MA25664EP1277745US20030101925CN1426402
CA2407349EA200201055AU2001048828