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Machine translation
1. (WO2001080889) PRODUCT AND PROCESS FOR REGULATION OF T CELL RESPONSES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2001/080889    International Application No.:    PCT/US2001/013861
Publication Date: 01.11.2001 International Filing Date: 26.04.2001
IPC:
A61K 9/00 (2006.01), A61K 38/20 (2006.01), A61K 39/39 (2006.01), A61K 39/395 (2006.01), C07K 16/24 (2006.01), C07K 16/28 (2006.01)
Applicants: NATIONAL JEWISH MEDICAL AND RESEARCH CENTER [US/US]; 1400 Jackson Street Denver, CO 80206 (US)
Inventors: MARRACK, Phillipa; (US).
KAPPLER, John, W.; (US).
KU, Chia, Chi; (US).
MURAKAMI, Masaaki; (US).
SAKAMOTO, Akemi; (JP)
Agent: DALLAS-PEDRETTI, Angela; Sheridan Ross P.C. Suite 1200 1560 Broadway Denver, CO 80202-5141 (US)
Priority Data:
60/199,763 26.04.2000 US
Title (EN) PRODUCT AND PROCESS FOR REGULATION OF T CELL RESPONSES
(FR) REGULATION DE LA REPONSE DES LYMPHOCYTES T ET PRODUIT A CET EFFET
Abstract: front page image
(EN)Disclosed is a method for increasing a memory T cell response by administering to a patient a composition that increases the activity of IL-15 and that decreases the activity of IL-2. Also disclosed is a vaccine adjuvant useful for increasing memory T cell responses. A method for inhibiting undesirable immune responses, such as autoimmune responses, is also disclosed, as is a composition useful in such a method. The composition includes a compound that increases the activity of IL-2 and in one embodiment, further includes a compound that decreases the activity of IL-15.
(FR)La présente invention concerne un procédé pour augmenter la réponse des lymphocytes T mémoire par administration à un patient d'une composition qui augmente l'activité de l'IL-15, et qui diminue l'activité de l'IL-2. L'invention concerne également un adjuvant vaccinal convenant pour l'augmentation des réponses des lymphocytes T mémoire. L'invention concerne aussi un procédé permettant d'inhiber les réponses immunitaires indésirables, telles que les réponses auto-immunes, ainsi qu'une composition convenant pour ce procédé. Cette composition inclut un composé qui augmente l'activité de l'IL-2, et qui, selon un mode de réalisation de l'invention, inclut également un composé qui diminue l'activité de l'IL-15.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)