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Machine translation
1. (WO2001080832) ADMINISTRATION OF A THIOL-BASED CHEMOPROTECTANT COMPOUND
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2001/080832    International Application No.:    PCT/US2001/040624
Publication Date: 01.11.2001 International Filing Date: 26.04.2001
Chapter 2 Demand Filed:    20.11.2001    
IPC:
A61K 9/08 (2006.01), A61K 31/195 (2006.01), A61K 31/198 (2006.01), A61K 31/661 (2006.01), A61K 38/06 (2006.01)
Applicants: OREGON HEALTH SCIENCES UNIVERSITY [US/US]; Technology and Research Collaborations, L335 3181 SW Sam Jackson Park Road Portland, OR 97201-3098 (US) (For All Designated States Except US).
GOVERNMENT OF THE UNITED STATES, d/b/a DEPARTMENT OF VETERANS AFFAIRS [US/US]; 810 Vermont Avenue NW Washington, DC 20420 (US) (For All Designated States Except US).
PAGEL, Michael, A. [US/US]; (US) (For US Only).
MULDOON, Leslie [US/US]; (US) (For US Only).
NEUWELT, Edward, A. [US/US]; (US) (For US Only)
Inventors: PAGEL, Michael, A.; (US).
MULDOON, Leslie; (US).
NEUWELT, Edward, A.; (US)
Agent: CONFORTI, Vita, G.; Davis Wright Tremaine LLP 2600 Century Square 1501 Fourth Avenue Seattle, WA 98101-1688 (US)
Priority Data:
60/199,936 26.04.2000 US
60/229,870 30.08.2000 US
Title (EN) ADMINISTRATION OF A THIOL-BASED CHEMOPROTECTANT COMPOUND
(FR) ADMINISTRATION D'UN COMPOSE CHIMIOPROTECTEUR A BASE DE THIOL
Abstract: front page image
(EN)A method of administration of a thiol-based chemoprotectant agent including NAC (N-acetylcysteine) and STS (sodium thiosulfate) that markedly affects biodistribution and protects against injury from diagnostic or therapeutic intra-arterial procedures. A method for treating or mitigating the side effects of cytotoxic cancer therapy for tumors located in the head or neck and brain tumors. The thiol-based chemoprotectant agent is administered intra-arterially with rapid and first pass uptake in organs and tissues other than the liver.
(FR)L'invention concerne une méthode d'administration d'un agent chimioprotecteur à base de thiol, comprenant du NAC (N-acétylcystéine) et du STS (thiosulfate de sodium), qui modifie sensiblement la biorépartition et protège contre les blessures consécutives à des procédures diagnostiques ou thérapeutiques intra-artérielles. L'invention porte également sur une méthode de traitement ou d'atténuation des effets secondaires du traitement anticancéreux cytotoxique contre les tumeurs situées dans la tête, le cou ou le cerveau. Ledit agent chimioprotecteur à base de thiol est administré par voie intra-artérielle, avec une absorption rapide et en une seule fois dans les organes et les tissus autres que le foie.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)