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1. (WO2001080823) COMPOSITION EXHIBITING ENHANCED FORMULATION STABILITY AND DELIVERY OF TROPICAL ACTIVE INGREDIENTS

Pub. No.:    WO/2001/080823    International Application No.:    PCT/IL2001/000370
Publication Date: Nov 1, 2001 International Filing Date: Apr 20, 2001
IPC: A61K 8/11
A61K 8/25
A61K 8/37
A61K 8/38
A61K 8/60
A61K 8/67
A61K 9/50
A61K 9/51
A61Q 5/00
A61Q 11/00
A61Q 17/04
A61Q 19/00
Applicants: SOL-GEL TECHNOLOGIES LTD.
LAPIDOT, Noa
MAGDASSI, Shlomo
AVNIR, David
ROTTMAN, Claudio
GANS, Orit
SERI-LEVY, Alon
Inventors: LAPIDOT, Noa
MAGDASSI, Shlomo
AVNIR, David
ROTTMAN, Claudio
GANS, Orit
SERI-LEVY, Alon
Title: COMPOSITION EXHIBITING ENHANCED FORMULATION STABILITY AND DELIVERY OF TROPICAL ACTIVE INGREDIENTS
Abstract:
A therapeutic or cosmetic composition for topical application, capable of stabilizing an active ingredient and delivering said ingredient, comprising a plurality of microcapsules having a core-shell structure. The microcapsules have a diameter of approximately 0.1 to 100 microns. The core of each microcapsule includes at least one active ingredient, and is encapsulated within a microcapsular shell, The shell is comprised of at least one inorganic polymer obtained by a sol-gel process, and the shell protects the active ingredient before topical application and releases the ingredient after topical application. This composition is useful to encapsulate active ingredients that are unstable in formulation, or are irritating to the skin. The present invention further discloses a process for the encapsulation of an active ingredient in the form of a dispersion within a hydrophobic phase.