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1. (WO2001072751) PYRROLOPYRIMIDINES AS TYROSINE KINASE INHIBITORS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2001/072751 International Application No.: PCT/US2000/008593
Publication Date: 04.10.2001 International Filing Date: 29.03.2000
Chapter 2 Demand Filed: 24.10.2001
IPC:
C07D 487/04 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
Applicants:
KNOLL GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG [DE/DE]; Knollstrasse 50 67061 Ludwigshafen, DE (AllExceptUS)
HIRST, Gavin, C. [GB/US]; US (UsOnly)
CALDERWOOD, David [GB/US]; US (UsOnly)
MUNSCHAUER, Rainer [DE/DE]; DE (UsOnly)
ARNOLD, Lee, D. [CA/US]; US (UsOnly)
JOHNSTON, David, N. [GB/GB]; GB (UsOnly)
RAFFERTY, Paul [GB/GB]; GB (UsOnly)
Inventors:
HIRST, Gavin, C.; US
CALDERWOOD, David; US
MUNSCHAUER, Rainer; DE
ARNOLD, Lee, D.; US
JOHNSTON, David, N.; GB
RAFFERTY, Paul; GB
Agent:
ELMORE, Carolyn, S. ; Hamilton, Brook, Smith & Reynolds, P.C. Two Militia Drive Lexington, MA 02421, US
Priority Data:
Title (EN) PYRROLOPYRIMIDINES AS TYROSINE KINASE INHIBITORS
(FR) PYRROLOPYRIMIDINES UTILISEES COMME INHIBITEURS DE TYROSINE KINASES
Abstract:
(EN) Chemical compounds having structural formula (I), and physiologically acceptable salts and metabolites thereof, are inhibitors of serine/threonine and tyrosine kinase activity. Several of the kinases, whose activity is inhibited by these chemical compounds, are involved in immunologic, hyperproliferative, or angiogenic processes. Thus, these chemical compounds can ameliorate disease states where angiogenesis or endothelial cell hyperproliferation is a factor. These compounds can be used to treat cancer and hyper proliferative disorders, rheumatiod arthritis, disorders of the immune system, transplant rejections and ifplammatory disorders.
(FR) L'invention concerne des composés chimiques ayant la formule structurale (I) ainsi que leurs sels et métabolites physiologiquement acceptables, lesquels sont des inhibiteurs de l'activité sérine/thréonine et tyrosine kinase. Plusieurs des kinases, dont l'activité est inhibée par ces composés chimiques, sont impliquées dans des processus immunologiques, hyperprolifératifs ou angiogéniques. Ainsi, ces composés chimiques peuvent améliorer des états pathologiques dans lesquels l'angiogénèse ou l'hyperprolifération de cellules endothéliales constituent un facteur. Ces composés peuvent être utilisés pour traiter le cancer ainsi que des troubles hyperprolifératifs, la polyarthrite rhumatoïde, des troubles du système immun, des rejets de greffe et des maladies inflammatoires.
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
AU2000240570