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1. WO2001062910 - IMMUNOSTIMULATORY OLIGONUCLEOTIDES

Publication Number WO/2001/062910
Publication Date 30.08.2001
International Application No. PCT/FR2001/000350
International Filing Date 07.02.2001
Chapter 2 Demand Filed 03.09.2001
IPC
C12N 15/11 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
CPC
A61K 2039/55561
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
555characterised by a specific combination antigen/adjuvant
55511Organic adjuvants
55561CpG containing adjuvants; Oligonucleotide containing adjuvants
A61P 37/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
02Immunomodulators
04Immunostimulants
C12N 15/117
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
117Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
C12N 2310/18
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2310Structure or type of the nucleic acid
10Type of nucleic acid
18acting by a non-sequence specific mechanism
Applicants
  • AVENTIS PASTEUR [FR]/[FR] (AllExceptUS)
  • BACHY, Monique [FR]/[FR] (UsOnly)
  • SODOYER, Régis [FR]/[FR] (UsOnly)
  • TRANNOY, Emanuelle [FR]/[FR] (UsOnly)
Inventors
  • BACHY, Monique
  • SODOYER, Régis
  • TRANNOY, Emanuelle
Agents
  • KERNEIS, Danièle
Priority Data
00/0205618.02.2000FR
Publication Language French (FR)
Filing Language French (FR)
Designated States
Title
(EN) IMMUNOSTIMULATORY OLIGONUCLEOTIDES
(FR) OLIGONUCLEOTIDES IMMUNOSTIMULANTS
Abstract
(EN)
The invention concerns an oligonucleotide capable of stimulating human cells of the immune system, characterised in that it comprises at least a nucleotide sequence corresponding to the formula 5'GCATGATTTTGAGCT3', wherein T represents Thymine, A Adenine, C Cytosine, and G Guanine, and it does not include CG dinucleotide wherein the Cytosine C is unmethylated. Said oligonucleotide is particularly useful as vaccine adjuvant.
(FR)
L'invention concerne un oligonucléotide capable de stimuler des cellules humaines du système immunitaire, caractérisé en ce qu'il comprend au moins une séquence nucléotidique ayant la formule suivant 5' GCATGATTTTGAGCT3', dans laquelle T signifie Thymine, A Adénine, C Cytosine, et G Guanine, et en ce qu'il est dépourvu de dinucléotide CG dans lequel la Cytosine C n'est pas méthylée. Un tel oligonucléotide trouve une application particulièrement intéressante comme adjuvant vaccinal.
Also published as
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