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1. WO2001062294 - PREVENTIVE OR THERAPEUTIC DRUGS FOR DERMATITISES CONTAINING CHYMASE INHIBITORS AS THE ACTIVE INGREDIENT

Publication Number WO/2001/062294
Publication Date 30.08.2001
International Application No. PCT/JP2001/001323
International Filing Date 22.02.2001
IPC
A61K 31/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
A61K 31/517 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
517ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
C07D 239/96 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
239Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
70condensed with carbocyclic rings or ring systems
72Quinazolines; Hydrogenated quinazolines
95with hetero atoms directly attached in positions 2 and 4
96Two oxygen atoms
CPC
A61K 31/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
A61K 31/517
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two ; or more; nitrogen atoms as the only ring heteroatoms, e.g. piperazine ; or tetrazines
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
517ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
A61P 17/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
A61P 17/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
02for treating wounds, ulcers, burns, scars, keloids, or the like
A61P 17/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
04Antipruritics
A61P 37/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
02Immunomodulators
06Immunosuppressants, e.g. drugs for graft rejection
Applicants
  • SUNTORY LIMITED [JP]/[JP] (AllExceptUS)
  • FUKAMI, Harukazu [JP]/[JP] (UsOnly)
  • TOMIMORI, Yoshiaki [JP]/[JP] (UsOnly)
  • FUKUDA, Yoshiaki [JP]/[JP] (UsOnly)
  • WATANABE, Naohiro [JP]/[JP] (UsOnly)
Inventors
  • FUKAMI, Harukazu
  • TOMIMORI, Yoshiaki
  • FUKUDA, Yoshiaki
  • WATANABE, Naohiro
Agents
  • ISHIDA, Takashi
Priority Data
2000-5050422.02.2000JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) PREVENTIVE OR THERAPEUTIC DRUGS FOR DERMATITISES CONTAINING CHYMASE INHIBITORS AS THE ACTIVE INGREDIENT
(FR) MEDICAMENTS PREVENTIFS OU THERAPEUTIQUES CONTENANT DES INHIBITEURS DE CHYMASE EN TANT QUE PRINCIPE ACTIF, POUR TRAITER DES DERMATITES
Abstract
(EN)
Preventive or therapeutic drugs for dermatitises accompanied with dimorphic inflammatory reactions and those caused by repeated exposure to antigens, which inhibit the progression of such dermatitises and are so safe by virtue of their being free from adverse effects as to bring about enhancement in the quality of daily life of a patient. Specifically, remedies for the above dermatitisescontaining chymase inhibitors as the active ingredient, wherein the chymase inhibitors are quinazoline derivatives of the general formula (I) or (II) or pharmacologically acceptable salts thereof.
(FR)
Médicaments préventifs ou thérapeutiques destinés à traiter des dermatites accompagnées de réactions inflammatoires en deux phases et celles provoquées par l'exposition répétée à des antigènes. Lesdits médicaments inhibent la progression de ces dermatites, et sont sûrs du fait qu'ils sont exempts d'effets secondaires, améliorant ainsi la qualité de vie du patient. La présente invention concerne spécifiquement des remèdes contre les dermatites susmentionnées, qui contiennent en tant que principe actif des inhibiteurs de chymase. Lesdits inhibiteurs de chymase sont des dérivés de quinazoline de formule générale (I) ou (II) ou des sels pharmacologiquement acceptables desdits dérivés.
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