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1. WO2001062253 - COMPOSITIONS AND METHODS FOR TREATMENT OF EPILEPSY

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[ EN ]

I claim:

1. A method of treating a mammal with an epileptic condition, comprising: administering to said mammal a pharmaceutical composition containing an effective amount of an N-phenyl substituted 2-pyridone compound and/or pharmaceutically
acceptable salts thereof.

2. A method, as defined in Claim 1, wherein: said 2-pyridone is administered in an amount of from about 2 to about 40 mg/kg of body weight per day.

3. A method, as defined in Claim 2, wherein: said 2-pyridone is administered orally in an amount of from about 5 to about 40 mg/kg of body weight per day.

4. A method, as defined in Claim 2, wherein: said 2-pyridone is administered parenterally in an amount of from about 2 to about 20 mg/kg of body weight per day.

5. A method, as defined in Claim 1, wherein: said 2-pyridone has the following general structural formula:


6. A method, as defined in Claim 1, wherein: said 2-pyridone comprises one or more compounds selected from the group
consisting of:
5-Methy-l-phenyl-2 (1H) -pyridone
5-Methyl-l- (3-nitrophenyl) -2- (1H) -pyridone
5-Methyl-l- (4' -methoxyphenyl) -2- (1H) -pyridone
5-Methyl-l-p-tolyl-2- ( 1H) -pyridone
5-Methyl-l- (3'-trifluoromethylphenyl) -2- (1H) -pyridone 1- (4'-Chlorophenyl) -5-methyl-2- (1H) -pyridone
5-Methyl-l- (2' -naphthyl) -2- ( 1H) -pyridone
5-Methyl-l- ( V -naphthyl ) -2- ( 1H) -pyridone 3-Ethyl-l-phenyl-2- ( 1H) -pyridone
6-Methyl-l-phenyl-2- ( 1H) -pyridone
3, 6-Dimethyl-l-phenyl-2- (1H) -pyridone
5-Methyl-l- (2' -thienyl) -2- ( 1H) -pyridone
1- (2' -Furyl) -5-methyl-2- (1H) -pyridone
5-Methyl-l- (5' -quinolyl) -2- (1H) -pyridone
5-Methyl-l- ( ' -pyridyl ) -2- ( 1H) -pyridone
5-Methyl-l- (3' -pyridyl) -2- (1H) -pyridone
5-Methyl-l- (2' -pyridyl) -2- ( 1H) -pyridone
5-Methyl-l- (2' -quinolyl) -2- ( 1H) -pyridone
5-Methyl-l- (4' -quinolyl) -2- (1H) -pyridone
5-Methyl-l- (2' -thiazolyl) -2- (1H) -pyridone
1- (2' -Imidazolyl) -5-methyl-2- (1H) -pyridone
5-Ethyl-l-phenyl-2- (1H) -pyridone
1- (4'-Nitrophenyl) -2- (1H) -pyridone
1, 3-Diphenyl-2- (1H) -pyridone
l-Phenyl-3- (4' -chlorophenyl) -2- (1H) -pyridone
1, 3-Diphenyl-5-methyl-2- (1H) -pyridone
3- (4' -Chlorophenyl) -5-methyl-l-phenyl-2- (1H) -pyridone

5-Methyl-3-phenyl-l- (2' -thienyl) -2- (1H) -pyridone

7. A composition for treating a mammal with an epileptic condition, comprising: a pharmaceutical composition containing an effective amount of an N-phenyl substituted 2-pyridone compound and/or pharmaceutically acceptable salts thereof.

8. A composition, as defined in Claim 7, wherein: said pyridone has the following general structural formula:



A

9. A composition, as defined in Claim 7, wherein: said 2-pyridone comprises one or more compounds selected from the group consisting of:
5-Methy-l-phenyl-2 (1H) -pyridone
5-Methyl-l- (3-nitrophenyl) -2- (1H) -pyridone 5-Methyl-l- (4' -methoxyphenyl) -2- (IH) -pyridone
5-Methyl-l-p-tolyl-2- (IH) -pyridone
5-Methyl-l- (3' -trifluoromethylphenyl) -2- (IH) -pyridone

1- (4' -Chlorophenyl) -5-methyl-2- (IH) -pyridone
5-Methyl-l- (2' -naphthyl) -2- (IH) -pyridone
5-Methyl-l- (1' -naphthyl) -2- (IH) -pyridone
3-Ethyl-l-phenyl-2- (IH) -pyridone
6-Methyl-l-phenyl-2- (IH) -pyridone
3, 6-Dimethyl-l-phenyl-2- (IH) -pyridone
5-Methyl-l- (2' -thienyl ) -2- ( IH) -pyridone
1- (2' -Furyl) -5-methyl-2- (IH) -pyridone
5-Methyl-l- (5' -quinolyl) -2- (IH) -pyridone
5-Methyl-l- (4' -pyridyl) -2- (IH) -pyridone
5-Methyl-l- (3' -pyridyl) -2- (IH) -pyridone
5-Methyl-l- (2' -pyridyl) -2- (IH) -pyridone
5-Methyl-l- (2' -quinolyl) -2- (IH) -pyridone
5-Methyl-l- (4' -quinolyl) -2- (IH) -pyridone
5-Methyl-l- (2' -thiazolyl) -2- (IH) -pyridone
1- (2' -Imidazolyl) -5-methyl-2- (IH) -pyridone
5-Ethyl-l-phenyl-2- (IH) -pyridone
1- (4'-Nitrophenyl) -2- (IH) -pyridone
1, 3-Diphenyl-2- (IH) -pyridone
l-Phenyl-3- (4' -chlorophenyl) -2- (IH) -pyridone
1, 3-Diphenyl-5-methyl-2- (IH) -pyridone
3- (4' -Chlorophenyl) -5-methyl-l-phenyl-2- (IH) -pyridone

5-Methyl-3-phenyl-l- (2' -thienyl) -2- (IH) -pyridone