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1. WO2001061344 - COMPUTATIONALLY TARGETED EVOLUTIONARY DESIGN

Publication Number WO/2001/061344
Publication Date 23.08.2001
International Application No. PCT/US2001/005043
International Filing Date 16.02.2001
Chapter 2 Demand Filed 17.09.2001
IPC
G01N 33/68 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
CPC
G01N 33/68
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
G16B 15/00
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
15ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
Applicants
  • CALIFORNIA INSTITUTE OF TECHNOLOGY [US]/[US] (AllExceptUS)
  • VOIGT, Christopher [US]/[US] (UsOnly)
  • MAYO, Stephen, L. [US]/[US] (UsOnly)
  • ARNOLD, Frances, H. [US]/[US] (UsOnly)
  • WANG, Zhen-Gang [US]/[US] (UsOnly)
Inventors
  • VOIGT, Christopher
  • MAYO, Stephen, L.
  • ARNOLD, Frances, H.
  • WANG, Zhen-Gang
Agents
  • SCHAFFER, Robert
Priority Data
60/183,17117.02.2000US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) COMPUTATIONALLY TARGETED EVOLUTIONARY DESIGN
(FR) CONCEPTION EVOLUTIVE A CIBLAGE COMPUTATIONNEL
Abstract
(EN) The invention relates to improved methods for directed evolution of polymers, including directed evolution of nucleic acids and proteins. Specifically, the methods of the invention include analytical methods for identifying 'structurally tolerant' residues of a polymer. Mutations of these, structurally tolerant residues are less likely to adversely affect desirable properties of a polymer sequence. The invention further provides improved methods for directed evolution wherein the structurally tolerant residues of a polymer are selectively mutated. Computer systems for implementing analytical methods of the invention are also provided.
(FR) L'invention concerne des procédés améliorés pour l'évolution dirigée de polymères, y compris l'évolution dirigée d'acides et de protéines. D'une manière plus spécifique, ces procédés comprennent des procédés analytiques permettant d'identifier des résidus 'structurellement tolérants' d'un polymère. Des mutations de ces résidus structurellement tolérants ont moins de chances d'affecter de manière défavorable des propriétés souhaitables d'une séquence polymère. L'invention concerne également des procédés améliorés pour l'évolution dirigée, dans lesquels les résidus structurellement tolérants d'un polymère sont mutés sélectivement. L'invention concerne en outre des systèmes informatiques permettant de mettre en oeuvre les procédés analytiques selon l'invention.
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