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1. WO2001061041 - MULTIPLE-SITE REACTION DEVICE AND METHOD

Publication Number WO/2001/061041
Publication Date 23.08.2001
International Application No. PCT/US2001/004884
International Filing Date 16.02.2001
Chapter 2 Demand Filed 18.09.2001
IPC
B01J 19/00 2006.1
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
19Chemical, physical or physico-chemical processes in general; Their relevant apparatus
B01L 3/00 2006.1
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
3Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
B01L 7/00 2006.1
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
7Heating or cooling apparatus; Heat insulating devices
CPC
B01J 19/0046
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
19Chemical, physical or physico-chemical processes in general; Their relevant apparatus
0046Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
B01J 19/0093
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
19Chemical, physical or physico-chemical processes in general; Their relevant apparatus
0093Microreactors, e.g. miniaturised or microfabricated reactors
B01J 2219/00286
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
2219Chemical, physical or physico-chemical processes in general; Their relevant apparatus
00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
00277Apparatus
00279Features relating to reactor vessels
00281Individual reactor vessels
00286Reactor vessels with top and bottom openings
B01J 2219/00418
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
2219Chemical, physical or physico-chemical processes in general; Their relevant apparatus
00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
00277Apparatus
00351Means for dispensing and evacuation of reagents
00418using pressure
B01J 2219/00454
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
2219Chemical, physical or physico-chemical processes in general; Their relevant apparatus
00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
00277Apparatus
00452Means for the recovery of reactants or products
00454by chemical cleavage from the solid support
B01J 2219/00495
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
2219Chemical, physical or physico-chemical processes in general; Their relevant apparatus
00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
00277Apparatus
00495Means for heating or cooling the reaction vessels
Applicants
  • ACLARA BIOSCIENCES INC. [US]/[US]
Inventors
  • SHARAT, Singh
  • CAO, Liching
  • HOOPER, Herbert, H.
  • ALBAGLI, David
  • ANDERSON, Rolfe
  • ZENG, Shulin
Agents
  • DEHLINGER, Peter, J.
  • VOSSIUS & PARTNER
Priority Data
60/183,62618.02.2000US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) MULTIPLE-SITE REACTION DEVICE AND METHOD
(FR) PROCEDE ET DISPOSITIF DE REACTION SUR PLUSIEURS SITES
Abstract
(EN) A method and device for performing a plurality of small-volume reactions simultaneously are disclosed. The device includes an elongate or planar channel and a port for introducing such bulk-phase medium into the channel, a plurality of discrete small-volume reaction regions within the channel, and a reaction-specific reagent releasably carried on a wall portion of each reaction region. In carrying out the method of the invention, a bulk phase medium containing common reactants is added to the channel. Upon release of reaction-specific reagent from the wall portions of the reaction regions, a reagent-specific reaction can occur simultaneously in each region. The channel is dimensioned to substantially prevent convective fluid flow among the reaction regions during such reactions.
(FR) L'invention porte sur un procédé et un dispositif permettant d'effectuer simultanément plusieurs réactions de petit volume. Ce dispositif comprend un canal allongé ou plan et un port pour l'introduction dans le canal d'un milieu en phase liquide volumique, une pluralité de régions de réaction distinctes, de petit volume, ménagées dans le canal et un réactif spécifique d'une réaction supporté de manière libérable sur une partie de paroi de chaque région de réaction. Pour réaliser ce procédé, on ajoute au canal un milieu en phase liquide volumique contenant des réactifs communs. Lors de la libération, à partir des parties de paroi des régions de réaction, d'un réactif spécifique d'une réaction, une réaction spécifique d'un réactif se produit simultanément dans chaque région. Le canal est dimensionné de manière à empêcher, au cours des réactions, un écoulement de fluide convectif dans les régions de réaction.
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