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1. WO2001061038 - METHOD FOR DETECTING A BIOLOGICAL ENTITY IN A SAMPLE

Publication Number WO/2001/061038
Publication Date 23.08.2001
International Application No. PCT/US2001/004104
International Filing Date 08.02.2001
Chapter 2 Demand Filed 08.06.2001
IPC
C12Q 1/68 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
H04L 12/24 2006.1
HELECTRICITY
04ELECTRIC COMMUNICATION TECHNIQUE
LTRANSMISSION OF DIGITAL INFORMATION, e.g. TELEGRAPHIC COMMUNICATION
12Data switching networks
02Details
24Arrangements for maintenance or administration
CPC
C12Q 1/6837
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6813Hybridisation assays
6834Enzymatic or biochemical coupling of nucleic acids to a solid phase
6837using probe arrays or probe chips
C12Q 1/6844
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6844Nucleic acid amplification reactions
C12Q 1/689
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6888for detection or identification of organisms
689for bacteria
Applicants
  • SCIENCE APPLICATIONS INTERNATIONAL CORP. [US]/[US]
Inventors
  • SCHAUDIES, Robert, Paul
  • ROBINSON, Doreen
Agents
  • MARCOU, George, T.
Priority Data
60/183,38818.02.2000US
60/190,69120.03.2000US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) METHOD FOR DETECTING A BIOLOGICAL ENTITY IN A SAMPLE
(FR) METHODE PERMETTANT DE DETECTER UNE ENTITE BIOLOGIQUE DANS UN ECHANTILLON
Abstract
(EN) The invention relates to the detection of a biological entity in a sample. More particularly, the invention relates to detection of specific pathogens from a possible presence of hundreds to thousands of distinct biological species. The invention provides new assays that can detect the presence of one or more biological entity in a sample out of a possible number of hundreds to thousands of distinct biological species. The method according to the invention for detecting a biological entity in a sample comprises randomly amplifying nucleic acids in the sample to produce labeled nucleic acids; hybridizing the labeled nucleic acids to an array of predetermined nucleic acids; and detecting the labeled nucleic acids that have hybridized to the array.
(FR) L'invention concerne la détection d'une entité biologique dans un échantillon. Elle concerne, plus particulièrement, la détection de pathogènes spécifiques provenant de la présence possible de centaines ou de milliers d'espèces biologiques distinctes. Elle permet d'effectuer de nouveaux criblages destinés à détecter la présence d'au moins une entité biologique dans un échantillon parmi les centaines et les milliers d'espèces biologiques distinctes possibles. La méthode de l'invention, qui permet de détecter une entité biologique dans un échantillon, comprend des acides nucléiques s'amplifiant de manière aléatoire afin de produire des acides nucléiques marqués; d'hybrider lesdits acides nucléiques marqués avec un ensemble d'acides nucléiques prédéterminés; et de détecter les acides nucléiques marqués qui ont été hybridés avec ledit ensemble.
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