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1. WO2001060796 - PHENOXYALKYLAMINE DERIVATIVES USEFUL AS OPIOID δ RECEPTOR AGONISTS

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Publication Number WO/2001/060796
Publication Date 23.08.2001
International Application No. PCT/JP2001/001116
International Filing Date 16.02.2001
Chapter 2 Demand Filed 16.02.2001
IPC
A61K 31/438 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
438the ring being spiro-condensed with carbocyclic or heterocyclic ring systems
A61K 31/445 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non-condensed pyridines; Hydrogenated derivatives thereof
445Non-condensed piperidines, e.g. piperocaine
A61K 31/451 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non-condensed pyridines; Hydrogenated derivatives thereof
445Non-condensed piperidines, e.g. piperocaine
451having a carbocyclic ring directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
A61K 31/454 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non-condensed pyridines; Hydrogenated derivatives thereof
445Non-condensed piperidines, e.g. piperocaine
4523containing further heterocyclic ring systems
454containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
A61K 31/4709 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
47Quinolines; Isoquinolines
4709Non-condensed quinolines containing further heterocyclic rings
A61K 31/517 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
517ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
CPC
A61K 31/438
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
438The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
A61K 31/445
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non condensed pyridines; Hydrogenated derivatives thereof
445Non condensed piperidines, e.g. piperocaine
A61K 31/451
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non condensed pyridines; Hydrogenated derivatives thereof
445Non condensed piperidines, e.g. piperocaine
451having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
A61K 31/454
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non condensed pyridines; Hydrogenated derivatives thereof
445Non condensed piperidines, e.g. piperocaine
4523containing further heterocyclic ring systems
454containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
A61K 31/4709
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
47Quinolines; Isoquinolines
4709Non-condensed quinolines and containing further heterocyclic rings
A61K 31/517
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two ; or more; nitrogen atoms as the only ring heteroatoms, e.g. piperazine ; or tetrazines
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
517ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
Applicants
  • MEIJI SEIKA KAISHA, LTD. [JP]/[JP] (AllExceptUS)
  • TSUSHIMA, Masaki [JP]/[JP] (UsOnly)
  • TADAUCHI, Kaori [JP]/[JP] (UsOnly)
  • ASAI, Kenji [JP]/[JP] (UsOnly)
  • MIIKE, Naoko [JP]/[JP] (UsOnly)
  • IMAI, Masako [JP]/[JP] (UsOnly)
  • KUDO, Toshiaki [JP]/[JP] (UsOnly)
Inventors
  • TSUSHIMA, Masaki
  • TADAUCHI, Kaori
  • ASAI, Kenji
  • MIIKE, Naoko
  • IMAI, Masako
  • KUDO, Toshiaki
Agents
  • IMAMURA, Masazumi
Priority Data
2000-4079118.02.2000JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) PHENOXYALKYLAMINE DERIVATIVES USEFUL AS OPIOID δ RECEPTOR AGONISTS
(FR) DERIVES DE PHENOXYALKYLAMINE UTILES EN TANT QU'AGONISTES DU RECEPTEUR OPIOIDE $g(d)
front page image
Abstract
(EN)
Drugs useful in the prevention and/or treatment of nervous system diseases, containing as the active ingredient compounds of the general formula (I) or pharmacologically acceptable salts thereof: (I) wherein X is a group represented by the general formula (II), (III), (IV), (V) or (VI); A is a saturated or unsaturated 3- to 6-membered carbocyclic group or the like; B is CH2 or the like; n is 0 to 2; R1 is hydrogen, halogeno, or the like; R2, R3, and R7 to R14 are each hydrogen, optionally substituted lower alkyl, or the like; R4 is hydrogen, optionally substituted lower alkyl, or the like; R5 is hydrogen, halogeno, or the like; and R6 is a saturated or unsaturated mono- or bicyclic carbocyclic group or the like, or alternatively, R5 and R6, R7 and R8, R9 and R10, and/or R11 and R12 may be united to form a cyclic structure.
(FR)
La présente invention concerne des médicaments utiles dans la prévention et/ou le traitement des maladies du système nerveux, qui contiennent en tant qu'ingrédient actif des composés de formule (I) ou des sels pharmaceutiquement acceptables de ces derniers. Dans la formule (I), X représente un groupe représenté par la formule (II), (III), (IV), (V) ou (VI) ; A représente un groupe carbocyclique à 3-6 chaînons saturé ou non saturé ou autre ; B représente CH2 ou autre ; n est compris entre 0 et 2 ; R1 représente hydrogène, halogéno ou autre ; R2, R3 et R7 à R14 représentent chacun hydrogène, alkyle inférieur facultativement substitué ou autre ; R4 représente hydrogène, alkyle inférieur facultativement substitué ou autre ; R5 représente hydrogène, halogéno ou autre ; et R6 représente un groupe carbocyclique monocyclique ou bicyclique saturé ou non saturé ou autre ou bien, R5 et R6, R7 et R8, R9 et R10, et/ou R11 et R12 peuvent être unis pour former une structure cyclique.
Also published as
AU2001232319
CA2400640
DE000060112725
EP1256575
ES2248281
JPWO2001060796
US20030171370
US20050148583
Latest bibliographic data on file with the International Bureau
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