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1. WO2001059116 - 19459 PROTEIN, A HUMAN G-PROTEIN COUPLED SEVEN TRANSMEMBRANE RECEPTOR

Publication Number WO/2001/059116
Publication Date 16.08.2001
International Application No. PCT/US2001/004446
International Filing Date 09.02.2001
Chapter 2 Demand Filed 07.09.2001
IPC
C07K 14/705 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
C07K 14/72 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
72for hormones
CPC
C07K 14/705
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
C07K 14/723
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
72for hormones
723G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
C07K 2319/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2319Fusion polypeptide
Applicants
  • MILLENNIUM PHARMACEUTICALS, INC. [US]/[US] (AllExceptUS)
  • GLUCKSMANN, Maria, Alexandra [AR]/[US] (UsOnly)
  • WHITE, David [US]/[US] (UsOnly)
Inventors
  • GLUCKSMANN, Maria, Alexandra
  • WHITE, David
Agents
  • COULTER, Kathryn, L.
Priority Data
60/181,30109.02.2000US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) 19459 PROTEIN, A HUMAN G-PROTEIN COUPLED SEVEN TRANSMEMBRANE RECEPTOR
(FR) PROTEINE 19459: UNE NOUVELLE PROTEINE A SEPT SEGMENTS TRANSMEMBRANAIRES
Abstract
(EN)
The present invention relates to a newly identified seven-transmembrane protein, potentially a receptor belonging to the superfamily of G-protein-coupled receptors. The invention also relates to polynucleotides encoding the protein. The invention further relates to methods using the polypeptides and polynucleotides as a target for diagnosis and treatment in 19459 protein-mediated or -related disorders. The invention further relates to drug-screening methods using the polypeptides and polynucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the polypeptides and polynucleotides. The invention further relates to procedures for producing the polypeptides and polynucleotides.
(FR)
L'invention concerne une protéine à sept segments transmembranaires nouvellement identifiée, récepteur potentiel appartenant à la super-famille des récepteurs couplés à la protéine G. Elle concerne également des polynucléotides codant pour cette protéine. Elle concerne des méthodes d'utilisation desdits polypeptides et polynucléotides comme cibles permettant de diagnostiquer et de traiter des troubles associés ou induits par la protéine 19459. Elle concerne des méthodes de criblage de médicaments utilisant les polypeptides et les polynucléotides pour identifier des agonistes et des antagonistes de diagnostic et de traitement. Elle concerne des agonistes et antagonistes à base de polypeptides et de polynucléotides. Elle concerne enfin des procédures permettant de produire lesdits polypeptides et polynucléotides.
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