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1. WO2001059075 - IMPROVED SIALYLATION OF GLYCOPROTEINS

Publication Number WO/2001/059075
Publication Date 16.08.2001
International Application No. PCT/US2001/003955
International Filing Date 07.02.2001
Chapter 2 Demand Filed 31.08.2001
IPC
C12N 9/90 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
90Isomerases (5.)
C12P 21/00 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
21Preparation of peptides or proteins
CPC
C12N 9/90
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes; Proenzymes; Compositions thereof
90Isomerases (5.)
C12P 21/005
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
21Preparation of peptides or proteins
005Glycopeptides, glycoproteins
Applicants
  • GENENTECH, INC. [US]/[US] (AE, AG, AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BY, BZ, CA, CF, CG, CH, CI, CM, CN, CR, CU, CY, CZ, DE, DK, DM, DZ, EE, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GR, GW, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MC, MD, MG, MK, ML, MN, MR, MW, MX, MZ, NE, NL, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, SN, SZ, TD, TG, TJ, TM, TR, TT, TZ, UA, UG, UZ, VN, YU, ZA, ZW)
  • RYLL, Thomas [DE]/[US] (UsOnly)
Inventors
  • RYLL, Thomas
Agents
  • DAIGNAULT, Ronald, A.
Priority Data
60/181,07408.02.2000US
60/191,52923.03.2000US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) IMPROVED SIALYLATION OF GLYCOPROTEINS
(FR) AMELIORATION CONCERNANT LA SIALYLATION DE GLYCOPROTEINES
Abstract
(EN) The present invention provides for cells and processes for producing glycoproteins having enhanced sialyation. The invention also provides for nucleic acid sequences encoding UDP-GlcNac 2-epimerases or modified UDP-GlcNac 2-epimerases. The modified UDP-GlcNac 2-epimerases have reduced binding to sialic acid.
(FR) La présente invention concerne des cellules et des procédés permettant de produire des glycoprotéines à sialylation accrue. En l'occurrence, on introduit dans la cellule une séquence d'acide nucléique codant une UDP-GlcNac 2-épimérase ayant subi une mutation, auquel cas l'épimérase ne subit aucune inhibition du fait de la liaison de l'acide sialique.
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