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1. WO2001058878 - 2-CARBOXAMIDE-BENZIMIDAZOLES USEFUL IN THE TREATMENT AND PREVENTION OF ISCHEMIC REPERFUSION INJURY

Publication Number WO/2001/058878
Publication Date 16.08.2001
International Application No. PCT/US2001/004211
International Filing Date 08.02.2001
Chapter 2 Demand Filed 13.07.2001
IPC
C07D 235/24 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
235Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
02condensed with carbocyclic rings or ring systems
04Benzimidazoles; Hydrogenated benzimidazoles
24with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
CPC
A61P 1/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
A61P 1/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
04for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
A61P 1/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
16for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
A61P 1/18
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
18for pancreatic disorders, e.g. pancreatic enzymes
A61P 11/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
A61P 11/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
06Antiasthmatics
Applicants
  • THE PROCTER & GAMBLE COMPANY [US]/[US] (AllExceptUS)
  • NIKOLAIDES, Nicholas [US]/[US] (UsOnly)
  • CHIANELLI, Donatella [IT]/[US] (UsOnly)
Inventors
  • NIKOLAIDES, Nicholas
  • CHIANELLI, Donatella
Common Representative
  • REED, T., David
Priority Data
60/181,23409.02.2000US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) 2-CARBOXAMIDE-BENZIMIDAZOLES USEFUL IN THE TREATMENT AND PREVENTION OF ISCHEMIC REPERFUSION INJURY
(FR) 2-CARBOXAMIDE-BENZIMIDAZOLES UTILES DANS LE TRAITEMENT ET LA PREVENTION DES LESIONS ISCHEMIQUES CONSECUTIVES A LA PERFUSION
Abstract
(EN) The subject invention relates to compounds having the structure: (I) wherein: (a) R1 is selected from the group consisting of alkyl, aryl, alkoxy, and aryloxy, the alkyl and aryl portions of preferred R1 having from 1 to about 14 carbon atoms; (b) R3 and R4 are independently selected from the group consisting of hydrogen, halo, alkyl, alkoxy, alkyl-aryloxy, alkylthio, amino, and mono- or dialkylaminio, the alkyl portions of preferred R3 and R4 having from 1 to about 8 carbon atoms; except that R3 and R4 are not both hydrogen; (c) each R5 is independently selected from the group consisting of hydrogen, halo, cyano, alkyl, hydroxy, alkoxy, thio, alkylthio, amino, and mono- or dialkylamino, the alkyl portions of preferred R5 having from 1 to about 8 carbon atoms.The subject invention further relates to compositions comprising these compound. The subject compounds are useful for preventing or treating reperfusion injury of a variety of tissues.
(FR) L'invention concerne des composés ayant la structure (I) ci-après. Dans cette structure: (a) R1 peut être alkyle, aryle, alcoxy, et aryloxy, sachant que les parties alkyle et aryle de la configuration préférée pour R1 ont entre 1 et environ 14 atomes de carbone; (b) R3 et R4 peuvent être indépendamment hydrogène, halo, alkyle, alcoxy, alkyl-aryloxy, alkylthio, amino, et mono- ou dialkylaminio, sachant que les parties alkyle de la configuration préférée pour R3 et R4 ont entre 1 et environ 8 atomes de carbone; à condition toutefois que R3 et R4 ne soient pas ensemble hydrogène; (c) chaque R5 peut être indépendamment hydrogène, halo, cyano, alkyle, hydroxy, alcoxy, thio, alkylthio, amino, et mono- ou dialkylamino, sachant que les parties alkyle de la configuration préférée pour R5 ont entre 1 et environ 8 atomes de carbone. L'invention concerne en outre des compositions renfermant ce type de composé. Les composés considérés sont utiles pour la prévention ou le traitement des lésions consécutives à la perfusion qui affectent une variété de tissus.
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