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1. WO2001058849 - SURFACE ACTIVE AGENTS DERIVED FROM 1-O-N?$g(a)¿-ACETYL-L-AMINOACYL ESTER 3-O-MONOACYL GLYCERIDES AND 1-O-N?$g(a)¿-ACETYL L-AMINOACYL ESTER 2,3-O-DIACYL GLYCERIDES TYPE AMINO ACIDS AND THE PREPARATION THEREOF

Publication Number WO/2001/058849
Publication Date 16.08.2001
International Application No. PCT/ES2001/000040
International Filing Date 08.02.2001
Chapter 2 Demand Filed 10.09.2001
IPC
A61K 9/107 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
107Emulsions
A61K 31/223 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
21Esters, e.g. nitroglycerine, selenocyanates
215of carboxylic acids
22of acyclic acids, e.g. pravastatin
223of alpha-amino acids
C07C 233/47 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
233Carboxylic acid amides
01having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
45having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
46with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
47having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
C11D 1/10 2006.01
CCHEMISTRY; METALLURGY
11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
1Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
02Anionic compounds
04Carboxylic acids or salts thereof
10Amino carboxylic acids; Imino carboxylic acids; Fatty acid condensates thereof
C11D 3/48 2006.01
CCHEMISTRY; METALLURGY
11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
3Other compounding ingredients of detergent compositions covered in group C11D1/101
48Medicinal or disinfecting agents
CPC
A61K 31/223
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
21Esters, e.g. nitroglycerine, selenocyanates
215of carboxylic acids
22of acyclic acids, e.g. pravastatin
223of alpha-aminoacids
A61K 9/107
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
107Emulsions ; ; Emulsion preconcentrates; Micelles
C07C 233/47
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
233Carboxylic acid amides
01having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
45having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
46with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
47having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
C11D 1/10
CCHEMISTRY; METALLURGY
11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
DDETERGENT COMPOSITIONS
1Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
02Anionic compounds
04Carboxylic acids or salts thereof
10Amino-carboxylic acids; Imino-carboxylic acids; Fatty acid condensates thereof
C11D 3/48
CCHEMISTRY; METALLURGY
11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
DDETERGENT COMPOSITIONS
3Other compounding ingredients of detergent compositions covered in group C11D1/00
48Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
Applicants
  • CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS [ES]/[ES] (AllExceptUS)
  • CLAPES SABORIT, Pere [ES]/[ES] (UsOnly)
  • MORAN BADENAS, Carmen [ES]/[ES] (UsOnly)
  • PEREZ MUÑOZ, Mª Lourdes [ES]/[ES] (UsOnly)
  • INFANTE MARTINEZ-PARDO, Mª Rosa [ES]/[ES] (UsOnly)
Inventors
  • CLAPES SABORIT, Pere
  • MORAN BADENAS, Carmen
  • PEREZ MUÑOZ, Mª Lourdes
  • INFANTE MARTINEZ-PARDO, Mª Rosa
Agents
  • UNGRIA LOPEZ, Javier
Priority Data
P 20000031811.02.2000ES
Publication Language Spanish (ES)
Filing Language Spanish (ES)
Designated States
Title
(EN) SURFACE ACTIVE AGENTS DERIVED FROM 1-O-N$g(a)-ACETYL-L-AMINOACYL ESTER 3-O-MONOACYL GLYCERIDES AND 1-O-N$g(a)-ACETYL L-AMINOACYL ESTER 2,3-O-DIACYL GLYCERIDES TYPE AMINO ACIDS AND THE PREPARATION THEREOF
(ES) TENSIOACTIVOS DERIVADOS DE AMINOACIDOS DEL TIPO 1-O-N$g(a)-ACETIL-L-AMINOACIL ESTER 3-O-MONOACIL GLICERIDOS Y 1-O-N$g(a)-ACETIL L-AMINOACIL ESTER 2,3-O-DIACIL GLICERIDOS Y SU PREPARACION
(FR) TENSIO-ACTIFS DERIVES D'AMINOACIDES DU TYPE 1-O-N$g(a)-ACETYL-L-AMINOACYL ESTER 3-O-MONOACYL GLYCERIDES ET 1-O-N$g(a)-ACETYL L-AMINOACYL ESTER 2,3-O-DIACYL GLYCERIDES ET LEUR PREPARATION
Abstract
(EN)
The invention concerns novel surface active compounds derived from monoacyl and diacyl glyceride type amino acids according to general formula (I) designed to act as surface active and antimicrobial agents. Activity will vary depending on the number of fatty chains, their length and the amino acid present in the structure. Purification of the intermediate and final products is carried out by means of liquid/liquid, liquid/solid extractions, crystallizations and ion exchange chromatography and preparation HPLC.
(ES)
La presente invención se refiere a nuevos compuestos tensioactivos derivados de aminoácidos del tipo mono y diacilglicéridos según fórmula general (I) diseñados para que actúen como agentes de superficie y antimicrobianos. Las variaciones en la actividad serán función del n° de cadenas grasas, la longitud de éstas y el aminoácido presente en la estructura. La purificación de los productos intermedios y finales se lleva a cabo mediante extracciones líquido/líquido, líquido/sólido, cristalizaciones, cromatografía de intercambio iónico y HPLC preparativo.
(FR)
La présente invention concerne de nouveaux composés tensio-actifs dérivés d'aminoacides du type mono et diacylglicéride, représentés par la formule générale (I) et conçus pour agir en tant qu'agents de surface à activité antimicrobienne. Les variations d'activité varieront en fonction du nombre de chaînes grasses, de leur longueur et de l'aminoacide présent dans la structure. La purification des produits intermédiaires et finaux s'obtient par extractions liquide-liquide, liquide-solide, par cristallisations, et par chromatographie par échange d'ions et CLHP préparative.
Also published as
Latest bibliographic data on file with the International Bureau